Viral infections in prostate carcinomas in Chilean patients

Hector Rodríguez; Jorge Levican; Juan P. Muñoz; Diego Carrillo; Mónica L. Acevedo; Aldo Gaggero; Oscar León; Tarik Gheit; Omar Espinoza-Navarro; Jorge Castillo; Iván Gallegos; Massimo Tommasino; Francisco Aguayo

doi:10.1186/s13027-015-0024-y

Viral infections in prostate carcinomas in Chilean patients

Título traducido de la contribución: Infecciones virales en carcinomas de próstata en pacientes chilenos

Hector Rodríguez
, Jorge Levican
, Juan P. Muñoz
, Diego Carrillo
, Mónica L. Acevedo
, Aldo Gaggero
, Oscar León
, Tarik Gheit
, Omar Espinoza-Navarro
, Jorge Castillo
, Iván Gallegos
, Massimo Tommasino
, Francisco Aguayo

Departamento de Biología

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

7 Citas (Scopus)

Resumen

Antecedentes: Se han detectado algunos virus en el cáncer de próstata; sin embargo, no se ha determinado su rol en el desarrollo de esta neoplasia. El objetivo de este estudio fue analizar la presencia y funcionalidad del virus del papiloma humano (VPH) y poliomavirus (BKPyV y JCPyV) en carcinomas de próstata en pacientes chilenos. Métodos: Se analizaron sesenta y nueve carcinomas primarios de próstata para detectar la presencia de VPH, BKPyV y JCPyV utilizando protocolos estándar de reacción en cadena de la polimerasa. Además, cuando las muestras fueron positivas para VPH, se analizaron las transcripciones del antígeno T grande (TAg) utilizando PCR con transcriptasa inversa. Resultados: No se detectaron VPH ni JCPyV en ninguna muestra (0/69, 0 %); mientras que BKPyV se detectó en 6/69 CaP (8,7 %). No encontramos una asociación estadísticamente significativa entre la presencia de BKPyV y la edad (p∈=∈0,198) o el puntaje de Gleason (p∈=∈0,268). Además, 2/6 (33 %) muestras positivas para BKPyV mostraron niveles detectables de transcritos de TAg. Conclusiones: No se observó asociación entre la presencia de VPH o JCPyV y el desarrollo de cáncer de próstata. La presencia de BKPyV en un pequeño subgrupo de carcinomas de próstata en pacientes chilenos podría indicar que este virus podría desempeñar un papel en el desarrollo de cáncer de próstata y requiere mayor investigación.

Título traducido de la contribución	Infecciones virales en carcinomas de próstata en pacientes chilenos
Idioma original	Inglés
Número de artículo	27
Publicación	Infectious Agents and Cancer
Volumen	10
N.º	1
DOI	https://doi.org/10.1186/s13027-015-0024-y
Estado	Publicada - 1 sep. 2015

Palabras clave

Cáncer
Próstata
Virus

ODS de las Naciones Unidas

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title = "Viral infections in prostate carcinomas in Chilean patients",

abstract = "Background: A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. Methods: Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. Results: HPV and JCPyV were not detected in any specimens (0/69, 0 \%); whereas, BKPyV was detected in 6/69 PCas (8.7 \%). We did not find a statistically significant association between the presence of BKPyV and age (p∈=∈0.198) or Gleason score (p∈=∈0.268). In addition, 2/6 (33 \%) BKPyV positive specimens showed detectable levels of TAg transcripts. Conclusions: There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.",

keywords = "Cancer, Prostate, Virus, C{\'a}ncer, Pr{\'o}stata, Virus",

author = "Hector Rodr{\'i}guez and Jorge Levican and Mu{\~n}oz, \{Juan P.\} and Diego Carrillo and Acevedo, \{M{\'o}nica L.\} and Aldo Gaggero and Oscar Le{\'o}n and Tarik Gheit and Omar Espinoza-Navarro and Jorge Castillo and Iv{\'a}n Gallegos and Massimo Tommasino and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2015 Rodr{\'i}guez et al.",

year = "2015",

month = sep,

day = "1",

doi = "10.1186/s13027-015-0024-y",

language = "English",

volume = "10",

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number = "1",

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T1 - Viral infections in prostate carcinomas in Chilean patients

AU - Rodríguez, Hector

AU - Levican, Jorge

AU - Muñoz, Juan P.

AU - Carrillo, Diego

AU - Acevedo, Mónica L.

AU - Gaggero, Aldo

AU - León, Oscar

AU - Gheit, Tarik

AU - Espinoza-Navarro, Omar

AU - Castillo, Jorge

AU - Gallegos, Iván

AU - Tommasino, Massimo

AU - Aguayo, Francisco

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Background: A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. Methods: Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. Results: HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p∈=∈0.198) or Gleason score (p∈=∈0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts. Conclusions: There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.

AB - Background: A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. Methods: Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. Results: HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p∈=∈0.198) or Gleason score (p∈=∈0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts. Conclusions: There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.

KW - Cancer

KW - Prostate

KW - Virus

KW - Cáncer

KW - Próstata

KW - Virus

UR - https://www.scopus.com/pages/publications/84940476448

U2 - 10.1186/s13027-015-0024-y

DO - 10.1186/s13027-015-0024-y

M3 - Article

AN - SCOPUS:84940476448

SN - 1750-9378

VL - 10

JO - Infectious Agents and Cancer

JF - Infectious Agents and Cancer

IS - 1

M1 - 27

ER -

Viral infections in prostate carcinomas in Chilean patients

Resumen

Palabras clave

ODS de las Naciones Unidas

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