The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.

Alejandro H. Corvalán; Jenny Ruedlinger; Tomas de Mayo; Iva Polakovicova; Patricio Gonzalez-Hormazabal; Francisco Aguayo

doi:10.3390/cancers11020217

The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.

Título traducido de la contribución: La diversidad filogeográfica del virus de Epstein-Barr y la ascendencia mixta en las Américas: otro modelo de coevolución alterada entre humanos y patógenos.

Alejandro H. Corvalán
, Jenny Ruedlinger
, Tomas de Mayo
, Iva Polakovicova
, Patricio Gonzalez-Hormazabal
, Francisco Aguayo

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

9 Citas (Scopus)

Resumen

El virus de Epstein-Barr (VEB) es un agente etiológico del cáncer gástrico con importantes variaciones a nivel mundial. Las caracterizaciones moleculares del VEB han mostrado variaciones filogeográficas entre poblaciones sanas y en enfermedades asociadas al VEB, en particular el fragmento cosegregado BamHI-I y el sitio de restricción XhoI del exón 1 del gen LMP-1. En el continente americano, ambas variantes cosegregadas están presentes en portadores del VEB, lo que concuerda con la historia de la migración humana asiática y europea a este continente. Además, se han encontrado nuevas variantes recombinantes que reflejan la composición genética de este continente. Sin embargo, en el caso del cáncer gástrico asociado al VEB (CG asociado al VEB), prevalece la cepa europea cosegregada con el fragmento BamHI-“i” y el sitio de restricción XhoI. Por lo tanto, proponemos que una coevolución alterada entre cepas filogeográficas virales y la ascendencia humana mixta en el continente americano podría explicar la alta prevalencia de este subtipo particular de cáncer gástrico. Esta región cosegregada contiene dos transcritos relevantes para el GC asociado al VEB: BARF-1 y miR-BART. Por lo tanto, podrían requerirse estudios de asociación de todo el genoma (GWAS) o la secuenciación dirigida de ambos transcritos para esclarecer su papel como posible causa de esta coevolución alterada.

Título traducido de la contribución	La diversidad filogeográfica del virus de Epstein-Barr y la ascendencia mixta en las Américas: otro modelo de coevolución alterada entre humanos y patógenos.
Idioma original	Inglés
Número de artículo	217
Publicación	Cancers
Volumen	11
N.º	2
DOI	https://doi.org/10.3390/cancers11020217
Estado	Publicada - 13 feb. 2019
Publicado de forma externa	Sí

Palabras clave

Virus de Epstein-Barr
Cáncer gástrico
Ascendencia humana
Filogeografía viral

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title = "The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.",

abstract = "Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in EBV-associated diseases, particularly the cosegregated BamHI-I fragment and XhoI restriction site of exon 1 of the LMP-1 gene. In the Americas, both cosegregated variants are present in EBV carriers, which aligns with the history of Asian and European human migration to this continent. Furthermore, novel recombinant variants have been found, reflecting the genetic makeup of this continent. However, in the case of EBV-associated gastric cancer (EBV-associated GC), the cosegregated European BamHI-“i” fragment and XhoI restriction site strain prevails. Thus, we propose that a disrupted coevolution between viral phylogeographical strains and mixed human ancestry in the Americas might explain the high prevalence of this particular gastric cancer subtype. This cosegregated region contains two relevant transcripts for EBV-associated GC, the BARF-1 and miR-BARTs. Thus, genome-wide association studies (GWAS) or targeted sequencing of both transcripts may be required to clarify their role as a potential source of this disrupted coevolution. ",

keywords = "Virus de Epstein-Barr, C{\'a}ncer g{\'a}strico, Ascendencia humana, Filogeograf{\'i}a viral, Epstein-Barr Virus, Gastric cancer, Human ancestry, Viral phylogeography",

author = "Corval{\'a}n, \{Alejandro H.\} and Jenny Ruedlinger and \{de Mayo\}, Tomas and Iva Polakovicova and Patricio Gonzalez-Hormazabal and Francisco Aguayo",

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doi = "10.3390/cancers11020217",

language = "English",

volume = "11",

journal = "Cancers",

issn = "2072-6694",

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T1 - The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.

AU - Corvalán, Alejandro H.

AU - Ruedlinger, Jenny

AU - de Mayo, Tomas

AU - Polakovicova, Iva

AU - Gonzalez-Hormazabal, Patricio

AU - Aguayo, Francisco

PY - 2019/2/13

Y1 - 2019/2/13

N2 - Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in EBV-associated diseases, particularly the cosegregated BamHI-I fragment and XhoI restriction site of exon 1 of the LMP-1 gene. In the Americas, both cosegregated variants are present in EBV carriers, which aligns with the history of Asian and European human migration to this continent. Furthermore, novel recombinant variants have been found, reflecting the genetic makeup of this continent. However, in the case of EBV-associated gastric cancer (EBV-associated GC), the cosegregated European BamHI-“i” fragment and XhoI restriction site strain prevails. Thus, we propose that a disrupted coevolution between viral phylogeographical strains and mixed human ancestry in the Americas might explain the high prevalence of this particular gastric cancer subtype. This cosegregated region contains two relevant transcripts for EBV-associated GC, the BARF-1 and miR-BARTs. Thus, genome-wide association studies (GWAS) or targeted sequencing of both transcripts may be required to clarify their role as a potential source of this disrupted coevolution.

AB - Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in EBV-associated diseases, particularly the cosegregated BamHI-I fragment and XhoI restriction site of exon 1 of the LMP-1 gene. In the Americas, both cosegregated variants are present in EBV carriers, which aligns with the history of Asian and European human migration to this continent. Furthermore, novel recombinant variants have been found, reflecting the genetic makeup of this continent. However, in the case of EBV-associated gastric cancer (EBV-associated GC), the cosegregated European BamHI-“i” fragment and XhoI restriction site strain prevails. Thus, we propose that a disrupted coevolution between viral phylogeographical strains and mixed human ancestry in the Americas might explain the high prevalence of this particular gastric cancer subtype. This cosegregated region contains two relevant transcripts for EBV-associated GC, the BARF-1 and miR-BARTs. Thus, genome-wide association studies (GWAS) or targeted sequencing of both transcripts may be required to clarify their role as a potential source of this disrupted coevolution.

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KW - Cáncer gástrico

KW - Ascendencia humana

KW - Filogeografía viral

KW - Epstein-Barr Virus

KW - Gastric cancer

KW - Human ancestry

KW - Viral phylogeography

UR - https://www.scopus.com/pages/publications/85062518580

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DO - 10.3390/cancers11020217

M3 - Review article

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SN - 2072-6694

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JO - Cancers

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The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.

Resumen

Palabras clave

ODS de las Naciones Unidas

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