TY - JOUR
T1 - Smart and sensitive nanomaterial-based electrochemical sensor for the determination of a poly (ADP-ribose) polymerase (PARP) inhibitor anticancer agent
AU - Erk, Nevin
AU - Vural, Özgül
AU - Bouali, Wiem
AU - Ayse Genc, Asena
AU - Gnanasekaran, Lalitha
AU - Karimi-Maleh, Hassan
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - In this research, we propose a novel approach for constructing a sensitive and selective electrochemical sensor utilizing high-quality multi-walled carbon nanotubes functionalized with amino groups (MWCNT-NH2) for the detection of Talazoparib (TLZ), a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, in real samples. The MWCNT-NH2-based sensor exhibited remarkable performance characteristics, including excellent repeatability, reproducibility, and high selectivity against various interferences. Under optimized conditions, the sensor demonstrated a wide linear concentration range of 1.0–5.0 μM, with a low limit of detection (LOD) of 0.201 μM. Substantiated by rigorous analysis of pharmaceutical and biological matrices, our methodology emerges as a paragon of reliability, boasting recovery rates within the satisfactory bracket of 96.38–105.25%. The successful application of the MWCNT-NH2-based sensor in practical sample analysis highlights its potential for implementation in clinical and pharmaceutical settings. This research not only advances the application of MWCNT-NH2 in electrochemical sensing but also opens new avenues for the development and monitoring of innovative anticancer treatments. The insights gained from our study have far-reaching implications, pointing toward a future where precision and innovation converge to improve patient care and treatment outcomes.
AB - In this research, we propose a novel approach for constructing a sensitive and selective electrochemical sensor utilizing high-quality multi-walled carbon nanotubes functionalized with amino groups (MWCNT-NH2) for the detection of Talazoparib (TLZ), a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, in real samples. The MWCNT-NH2-based sensor exhibited remarkable performance characteristics, including excellent repeatability, reproducibility, and high selectivity against various interferences. Under optimized conditions, the sensor demonstrated a wide linear concentration range of 1.0–5.0 μM, with a low limit of detection (LOD) of 0.201 μM. Substantiated by rigorous analysis of pharmaceutical and biological matrices, our methodology emerges as a paragon of reliability, boasting recovery rates within the satisfactory bracket of 96.38–105.25%. The successful application of the MWCNT-NH2-based sensor in practical sample analysis highlights its potential for implementation in clinical and pharmaceutical settings. This research not only advances the application of MWCNT-NH2 in electrochemical sensing but also opens new avenues for the development and monitoring of innovative anticancer treatments. The insights gained from our study have far-reaching implications, pointing toward a future where precision and innovation converge to improve patient care and treatment outcomes.
KW - Anticancer medication
KW - Electrochemical sensor
KW - Multi-walled carbon nanotubes
KW - Pharmaceutical analysis
KW - Selectivity
KW - Sensitivity
KW - Talazoparib
UR - https://www.scopus.com/pages/publications/85172886794
U2 - 10.1016/j.envres.2023.117082
DO - 10.1016/j.envres.2023.117082
M3 - Article
C2 - 37699471
AN - SCOPUS:85172886794
SN - 0013-9351
VL - 238
JO - Environmental Research
JF - Environmental Research
M1 - 117082
ER -