Muscarinic Receptors Associated with Cancer

Gloria M. Calaf; Leodan A. Crispin; Juan P. Muñoz; Francisco Aguayo; Tammy C. Bleak

doi:10.3390/cancers14092322

Muscarinic Receptors Associated with Cancer

Título traducido de la contribución: Receptores muscarínicos asociados al cáncer

Gloria M. Calaf
, Leodan A. Crispin
, Juan P. Muñoz
, Francisco Aguayo
, Tammy C. Bleak

Instituto de Alta Investigación

Universidad de Tarapacá
Universidad de Chile

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

22 Citas (Scopus)

Resumen

El cáncer se ha considerado la patología del siglo y factores como el ambiente pueden desempeñar un papel etiológico importante. Se ha demostrado la capacidad de los agonistas muscarínicos para estimular el crecimiento y de los antagonistas de los receptores muscarínicos para inhibirlo en cáncer de mama, melanoma, pulmón, estómago, colon, páncreas, ovario, próstata y cerebro. Este trabajo tuvo como objetivo estudiar la correlación entre los receptores del factor de crecimiento epidérmico y los receptores muscarínicos colinérgicos, las diferencias de supervivencia ajustadas por el estadio clínico y la asociación entre la expresión génica y el nivel de infiltración inmunitaria en cánceres humanos de mama, pulmón, estómago, colon, hígado, próstata y glioblastoma. Por lo tanto, la modulación de los receptores muscarínicos colinérgicos se presenta como una alternativa terapéutica atractiva debido a las complejas vías de señalización implicadas.

Título traducido de la contribución	Receptores muscarínicos asociados al cáncer
Idioma original	Inglés
Número de artículo	2322
Publicación	Cancers
Volumen	14
N.º	9
DOI	https://doi.org/10.3390/cancers14092322
Estado	Publicada - 6 may 2022

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Palabras clave

Mama
Cáncer
Colorrectal
Gástrico
Glioblastoma
Hígado
Pulmón
Receptores muscarínicos
Próstata

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@article{4b3a678506f2451b97f92c215bb34d6f,

title = "Muscarinic Receptors Associated with Cancer",

abstract = "Cancer has been considered the pathology of the century and factors such as the environment may play an important etiological role. The ability of muscarinic agonists to stimulate growth and muscarinic receptor antagonists to inhibit tumor growth has been demonstrated for breast, melanoma, lung, gastric, colon, pancreatic, ovarian, prostate, and brain cancer. This work aimed to study the correlation between epidermal growth factor receptors and cholinergic muscarinic receptors, the survival differences adjusted by the stage clinical factor, and the association between gene expression and immune infiltration level in breast, lung, stomach, colon, liver, prostate, and glioblastoma human cancers. Thus, targeting cholinergic muscarinic receptors appears to be an attractive therapeutic alternative due to the complex signaling pathways involved.",

keywords = "Breast, Cancer, Colorectal, Gastric, Glioblastoma, Liver, Lung, Muscarinic receptors, Prostate, Mama, C{\'a}ncer, Colorrectal, G{\'a}strico, Glioblastoma, H{\'i}gado, Pulm{\'o}n, Receptores muscar{\'i}nicos, Pr{\'o}stata",

author = "Calaf, \{Gloria M.\} and Crispin, \{Leodan A.\} and Mu{\~n}oz, \{Juan P.\} and Francisco Aguayo and Bleak, \{Tammy C.\}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "6",

doi = "10.3390/cancers14092322",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

TY - JOUR

T1 - Muscarinic Receptors Associated with Cancer

AU - Calaf, Gloria M.

AU - Crispin, Leodan A.

AU - Muñoz, Juan P.

AU - Aguayo, Francisco

AU - Bleak, Tammy C.

PY - 2022/5/6

Y1 - 2022/5/6

N2 - Cancer has been considered the pathology of the century and factors such as the environment may play an important etiological role. The ability of muscarinic agonists to stimulate growth and muscarinic receptor antagonists to inhibit tumor growth has been demonstrated for breast, melanoma, lung, gastric, colon, pancreatic, ovarian, prostate, and brain cancer. This work aimed to study the correlation between epidermal growth factor receptors and cholinergic muscarinic receptors, the survival differences adjusted by the stage clinical factor, and the association between gene expression and immune infiltration level in breast, lung, stomach, colon, liver, prostate, and glioblastoma human cancers. Thus, targeting cholinergic muscarinic receptors appears to be an attractive therapeutic alternative due to the complex signaling pathways involved.

AB - Cancer has been considered the pathology of the century and factors such as the environment may play an important etiological role. The ability of muscarinic agonists to stimulate growth and muscarinic receptor antagonists to inhibit tumor growth has been demonstrated for breast, melanoma, lung, gastric, colon, pancreatic, ovarian, prostate, and brain cancer. This work aimed to study the correlation between epidermal growth factor receptors and cholinergic muscarinic receptors, the survival differences adjusted by the stage clinical factor, and the association between gene expression and immune infiltration level in breast, lung, stomach, colon, liver, prostate, and glioblastoma human cancers. Thus, targeting cholinergic muscarinic receptors appears to be an attractive therapeutic alternative due to the complex signaling pathways involved.

KW - Breast

KW - Cancer

KW - Colorectal

KW - Gastric

KW - Glioblastoma

KW - Liver

KW - Lung

KW - Muscarinic receptors

KW - Prostate

KW - Mama

KW - Cáncer

KW - Colorrectal

KW - Gástrico

KW - Glioblastoma

KW - Hígado

KW - Pulmón

KW - Receptores muscarínicos

KW - Próstata

UR - https://www.scopus.com/pages/publications/85132257720

U2 - 10.3390/cancers14092322

DO - 10.3390/cancers14092322

M3 - Review article

AN - SCOPUS:85132257720

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 9

M1 - 2322

ER -

Muscarinic Receptors Associated with Cancer

Resumen

ODS de las Naciones Unidas

Palabras clave

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