Human papillomavirus in breast carcinogenesis: A passenger, a cofactor, or a causal agent?

Rancés Blanco; Diego Carrillo-Beltrán; Juan P. Muñoz; Alejandro H. Corvalán; Gloria M. Calaf; Francisco Aguayo

doi:10.3390/biology10080804

Human papillomavirus in breast carcinogenesis: A passenger, a cofactor, or a causal agent?

Título traducido de la contribución: Virus del papiloma humano en la carcinogénesis mamaria: ¿Pasajero, cofactor o agente causal?

Rancés Blanco
, Diego Carrillo-Beltrán
, Juan P. Muñoz
, Alejandro H. Corvalán
, Gloria M. Calaf
, Francisco Aguayo

Universidad de Chile
Universidad de Tarapacá
Pontificia Universidad Católica de Chile
Columbia University

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

19 Citas (Scopus)

Resumen

El cáncer de mama (CM) es la neoplasia maligna más diagnosticada en mujeres a nivel mundial, así como la principal causa de muerte por cáncer en este sexo. Diversos estudios han identificado el virus del papiloma humano (VPH) como un posible factor de riesgo para el desarrollo del CM. Si bien existen vacunas que protegen contra la infección por VPH oncogénico disponibles comercialmente, persisten disparidades a nivel mundial debido a su elevado costo. Resulta interesante que numerosos autores hayan detectado una mayor prevalencia de infección por VPH de alto riesgo (VPH-AR) en muestras de CM en comparación con tejidos no tumorales. Por lo tanto, se ha sugerido que la infección por VPH-AR podría desempeñar un papel en la carcinogénesis mamaria en algunos casos. Se requiere evidencia epidemiológica y experimental adicional sobre el papel de la infección por VPH-AR en el desarrollo y la progresión del CM.

Título traducido de la contribución	Virus del papiloma humano en la carcinogénesis mamaria: ¿Pasajero, cofactor o agente causal?
Idioma original	Inglés
Número de artículo	804
Publicación	Biology
Volumen	10
N.º	8
DOI	https://doi.org/10.3390/biology10080804
Estado	Publicada - 19 ago. 2021

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Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Palabras clave

Mama
Cáncer
Virus del papiloma humano

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@article{b4b7a39c5c844b7bbee9eef15597b3f0,

title = "Human papillomavirus in breast carcinogenesis: A passenger, a cofactor, or a causal agent?",

abstract = "Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC.",

keywords = "Breast, Cancer, Human papillomavirus, Mama, C{\'a}ncer, Virus del papiloma humano",

author = "Ranc{\'e}s Blanco and Diego Carrillo-Beltr{\'a}n and Mu{\~n}oz, \{Juan P.\} and Corval{\'a}n, \{Alejandro H.\} and Calaf, \{Gloria M.\} and Francisco Aguayo",

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year = "2021",

month = aug,

day = "19",

doi = "10.3390/biology10080804",

language = "English",

volume = "10",

journal = "Biology",

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TY - JOUR

T1 - Human papillomavirus in breast carcinogenesis

T2 - A passenger, a cofactor, or a causal agent?

AU - Blanco, Rancés

AU - Carrillo-Beltrán, Diego

AU - Muñoz, Juan P.

AU - Corvalán, Alejandro H.

AU - Calaf, Gloria M.

AU - Aguayo, Francisco

PY - 2021/8/19

Y1 - 2021/8/19

N2 - Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC.

AB - Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC.

KW - Breast

KW - Cancer

KW - Human papillomavirus

KW - Mama

KW - Cáncer

KW - Virus del papiloma humano

UR - https://www.scopus.com/pages/publications/85113939746

U2 - 10.3390/biology10080804

DO - 10.3390/biology10080804

M3 - Review article

AN - SCOPUS:85113939746

SN - 2079-7737

VL - 10

JO - Biology

JF - Biology

IS - 8

M1 - 804

ER -

Human papillomavirus in breast carcinogenesis: A passenger, a cofactor, or a causal agent?

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Huella

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