Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.

Francisco Aguayo; Chihaya Koriyama; Carolina González; Sandra Ampuero; Oslando Padilla; y otros autores.

doi:10.1186/1750-9378-6-7

Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.

Título traducido de la contribución: Infecciones por virus del papiloma humano y virus de Epstein-Barr en cáncer de mama de Chile.

Francisco Aguayo
, Chihaya Koriyama
, Carolina González
, Sandra Ampuero
, Oslando Padilla
, y otros autores.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

64 Citas (Scopus)

Resumen

Antecedentes: El virus del papiloma humano (VPH) y el virus de Epstein Barr (VEB) se han encontrado en carcinomas de mama (CM) en todo el mundo. En este estudio, se analizaron cincuenta y cinco CM de Chile para detectar la presencia de VPH y VEB. Además, se determinó la carga viral/estado físico del VPH-16 y las expresiones de E6/E7. Resultados: La amplificación de un gen constitutivo mostró que 46/55 muestras (84%) tenían ADN amplificable. El VPH-16 se detectó en 4/46 CM (8,7%) y el VEB se detectó en 3/46 (6,5%) CM. El análisis del estado físico del VPH-16 mostró que este virus estaba integrado en todos los tumores con una carga viral relativamente baja (rango: 0,14 a 33,8 copias/célula). Sin embargo, no se detectaron transcripciones de E6 y E7 en ninguna muestra positiva para VPH-16. Mediante un modelo de regresión de Cox, se encontró una asociación estadísticamente significativa entre la presencia de VEB y una baja supervivencia (p = 0,013). Conclusiones: Los hallazgos de este estudio sugieren que es improbable que el VPH o el VEB desempeñen un papel directo en la etiología del cáncer de mama.

Título traducido de la contribución	Infecciones por virus del papiloma humano y virus de Epstein-Barr en cáncer de mama de Chile.
Idioma original	Inglés
Número de artículo	7
Publicación	Infectious Agents and Cancer
Volumen	6
N.º	1
DOI	https://doi.org/10.1186/1750-9378-6-7
Estado	Publicada - 23 jun. 2011
Publicado de forma externa	Sí

Palabras clave

Mama
Cáncer
VPH
Integración
Virus del papiloma

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10.1186/1750-9378-6-7

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@article{b308e5bc093648f584aa8c0efe2772c5,

title = "Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.",

abstract = "Background: Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results: The amplification of a housekeeping gene showed that 46/55 samples (84\%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7\%) and EBV was detected in 3/46 (6.5\%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions: The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.",

keywords = "Mama, C{\'a}ncer, VPH, Integraci{\'o}n, Virus del papiloma, Breast, Cancer, HPV, Integration, Papillomavirus",

author = "Francisco Aguayo and Chihaya Koriyama and Carolina Gonz{\'a}lez and Sandra Ampuero and Oslando Padilla and \{and other authors.\}",

year = "2011",

month = jun,

day = "23",

doi = "10.1186/1750-9378-6-7",

language = "English",

volume = "6",

journal = "Infectious Agents and Cancer",

issn = "1750-9378",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.

AU - Aguayo, Francisco

AU - Koriyama, Chihaya

AU - González, Carolina

AU - Ampuero, Sandra

AU - Padilla, Oslando

AU - and other authors.

PY - 2011/6/23

Y1 - 2011/6/23

N2 - Background: Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results: The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions: The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.

AB - Background: Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined. Results: The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013). Conclusions: The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.

KW - Mama

KW - Cáncer

KW - VPH

KW - Integración

KW - Virus del papiloma

KW - Breast

KW - Cancer

KW - HPV

KW - Integration

KW - Papillomavirus

UR - https://www.scopus.com/pages/publications/79959414288

U2 - 10.1186/1750-9378-6-7

DO - 10.1186/1750-9378-6-7

M3 - Article

C2 - 21699721

SN - 1750-9378

VL - 6

JO - Infectious Agents and Cancer

JF - Infectious Agents and Cancer

IS - 1

M1 - 7

ER -

Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile.

Resumen

Palabras clave

ODS de las Naciones Unidas

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Huella

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