Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.

Andrea Maturana-Ramírez; Iris Espinoza; Montserrat Reyes; Juan Pablo Aitken; Francisco Aguayo; Steffen Hartel; Gonzalo Rojas-Alcayaga

Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.

Título traducido de la contribución: Mayor densidad de vasos sanguíneos en comparación con los vasos linfáticos en el carcinoma de células escamosas oral.

Andrea Maturana-Ramírez
, Iris Espinoza
, Montserrat Reyes
, Juan Pablo Aitken
, Francisco Aguayo
, Steffen Hartel
, Gonzalo Rojas-Alcayaga

Universidad de Chile

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

Introducción: El carcinoma oral de células escamosas (COCE) se caracteriza por la invasión local y el desarrollo de metástasis cervicales. En la lengua, se ha demostrado una asociación entre la invasión de los vasos linfáticos y el desarrollo de metástasis en los ganglios linfáticos regionales. Además, la invasión de los vasos sanguíneos se asocia con mayor recurrencia y peor pronóstico. Por lo tanto, la presencia y densidad de vasos linfáticos y sanguíneos en los tejidos intratumorales y peritumorales podrían desempeñar un papel importante en la progresión, diseminación y metástasis de los carcinomas. Sin embargo, la evidencia sobre el COCE es inconclusa. El objetivo de este estudio fue determinar la comparación y la asociación entre las densidades de vasos linfáticos (CD2-40) y sanguíneos (CD34) en tejido intratumoral de COCE. Materiales y métodos: Se obtuvieron treinta y siete casos diagnosticados como COCE entre los años 2000 y 2008 del Servicio de Anatomía Patológica de la Facultad de Odontología de la Universidad de Chile. Se utilizaron los marcadores inmunohistoquímicos D2-40 y CD34, y se determinaron las densidades (mm²) de vasos linfáticos (DVL) y sanguíneos (DVS) en la región intratumoral. Se evaluó la relación entre los valores de DVL y DVS. Resultados: Se observó una asociación significativa entre la expresión de CD34 y D2-40 (rho=0,4, p < 0,05) y entre la DVL y la localización en la lengua (p=0,019). La DVS fue mayor (128,0 vasos/mm²) que la DVL (42,9 vasos/mm²), y se encontró una correlación positiva entre ambas. Conclusiones: En el carcinoma oral de células escamosas (COCE), la DVS es mayor que la DVL, y existe una correlación moderada entre ambas.

Título traducido de la contribución	Mayor densidad de vasos sanguíneos en comparación con los vasos linfáticos en el carcinoma de células escamosas oral.
Idioma original	Inglés
Páginas (desde-hasta)	13677-13686
Número de páginas	9
Publicación	International Journal of Clinical and Experimental Pathology
Volumen	8
N.º	10
Estado	Publicada - 1 oct 2015
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Palabras clave

Vaso sanguíneo
Vaso linfático
Cáncer oral

Otros archivos y enlaces

Citar esto

@article{7af3c566e70e4501881adea369a845c3,

title = "Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.",

abstract = "Introduction: Oral squamous cell carcinoma (OSCC) is characterized by local invasion and the development of cervical metastasis. In the tongue, an association between the invasion of the lymphatic vessels and the development of metastasis in the regional lymph nodes has been demonstrated. Moreover, invasion of the blood vessels is associated with greater recurrence and poorer prognoses. Therefore, the presence and density of lymphatic and blood vessels in intra- and peritumoral tissues should play an important role in the progression, dissemination and metastasis of carcinomas. However, the evidence regarding OSCC is inconclusive. The aim of this study was to determine the comparison and association between the lymphatic (D2-40) and blood vessel (CD34) densities in intratumoral OSCC tissue. Materials and Methods: Thirty-seven cases diagnosed as OSCC between the years 2000 and 2008 were obtained from the Anatomic Pathology Service of the School of Dentistry, University of Chile. The immunohistochemical markers D2-40 and CD34 were used, and the densities (mm2) of lymphatic vessels (LVD) and blood vessels (BVD) in the intratumoral region were determined. The relationship between LVD and BVD values was evaluated. Results: There were significant association between the CD34 and D2-40 expression (rho=0.4, P < 0.05) and between the LVD and the location in the tongue (P=0.019). The BVD was greater (128.0 vessels/mm2) than the LVD (42.9 vessels/mm2), and there was a positive correlation between the LVD and BVD. Conclusions: In OSCC, the BVD is greater than the LVD, and there is a moderate correlation between the two quantities.",

keywords = "Vaso sangu{\'i}neo, Vaso linf{\'a}tico, C{\'a}ncer oral, Blood vessel, Lymphatic vessel, Oral cancer",

author = "Andrea Maturana-Ram{\'i}rez and Iris Espinoza and Montserrat Reyes and Aitken, \{Juan Pablo\} and Francisco Aguayo and Steffen Hartel and Gonzalo Rojas-Alcayaga",

year = "2015",

month = oct,

day = "1",

language = "English",

volume = "8",

pages = "13677--13686",

journal = "International Journal of Clinical and Experimental Pathology",

issn = "1936-2625",

number = "10",

}

Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma. / Maturana-Ramírez, Andrea; Espinoza, Iris; Reyes, Montserrat et al.
En: International Journal of Clinical and Experimental Pathology, Vol. 8, N.º 10, 01.10.2015, p. 13677-13686.

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

TY - JOUR

T1 - Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.

AU - Maturana-Ramírez, Andrea

AU - Espinoza, Iris

AU - Reyes, Montserrat

AU - Aitken, Juan Pablo

AU - Aguayo, Francisco

AU - Hartel, Steffen

AU - Rojas-Alcayaga, Gonzalo

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Introduction: Oral squamous cell carcinoma (OSCC) is characterized by local invasion and the development of cervical metastasis. In the tongue, an association between the invasion of the lymphatic vessels and the development of metastasis in the regional lymph nodes has been demonstrated. Moreover, invasion of the blood vessels is associated with greater recurrence and poorer prognoses. Therefore, the presence and density of lymphatic and blood vessels in intra- and peritumoral tissues should play an important role in the progression, dissemination and metastasis of carcinomas. However, the evidence regarding OSCC is inconclusive. The aim of this study was to determine the comparison and association between the lymphatic (D2-40) and blood vessel (CD34) densities in intratumoral OSCC tissue. Materials and Methods: Thirty-seven cases diagnosed as OSCC between the years 2000 and 2008 were obtained from the Anatomic Pathology Service of the School of Dentistry, University of Chile. The immunohistochemical markers D2-40 and CD34 were used, and the densities (mm2) of lymphatic vessels (LVD) and blood vessels (BVD) in the intratumoral region were determined. The relationship between LVD and BVD values was evaluated. Results: There were significant association between the CD34 and D2-40 expression (rho=0.4, P < 0.05) and between the LVD and the location in the tongue (P=0.019). The BVD was greater (128.0 vessels/mm2) than the LVD (42.9 vessels/mm2), and there was a positive correlation between the LVD and BVD. Conclusions: In OSCC, the BVD is greater than the LVD, and there is a moderate correlation between the two quantities.

AB - Introduction: Oral squamous cell carcinoma (OSCC) is characterized by local invasion and the development of cervical metastasis. In the tongue, an association between the invasion of the lymphatic vessels and the development of metastasis in the regional lymph nodes has been demonstrated. Moreover, invasion of the blood vessels is associated with greater recurrence and poorer prognoses. Therefore, the presence and density of lymphatic and blood vessels in intra- and peritumoral tissues should play an important role in the progression, dissemination and metastasis of carcinomas. However, the evidence regarding OSCC is inconclusive. The aim of this study was to determine the comparison and association between the lymphatic (D2-40) and blood vessel (CD34) densities in intratumoral OSCC tissue. Materials and Methods: Thirty-seven cases diagnosed as OSCC between the years 2000 and 2008 were obtained from the Anatomic Pathology Service of the School of Dentistry, University of Chile. The immunohistochemical markers D2-40 and CD34 were used, and the densities (mm2) of lymphatic vessels (LVD) and blood vessels (BVD) in the intratumoral region were determined. The relationship between LVD and BVD values was evaluated. Results: There were significant association between the CD34 and D2-40 expression (rho=0.4, P < 0.05) and between the LVD and the location in the tongue (P=0.019). The BVD was greater (128.0 vessels/mm2) than the LVD (42.9 vessels/mm2), and there was a positive correlation between the LVD and BVD. Conclusions: In OSCC, the BVD is greater than the LVD, and there is a moderate correlation between the two quantities.

KW - Vaso sanguíneo

KW - Vaso linfático

KW - Cáncer oral

KW - Blood vessel

KW - Lymphatic vessel

KW - Oral cancer

UR - https://www.scopus.com/pages/publications/85013218847

UR - http://europepmc.org/abstract/med/26722595

M3 - Article

C2 - 26722595

SN - 1936-2625

VL - 8

SP - 13677

EP - 13686

JO - International Journal of Clinical and Experimental Pathology

JF - International Journal of Clinical and Experimental Pathology

IS - 10

ER -

Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.

Resumen

ODS de las Naciones Unidas

Palabras clave

Otros archivos y enlaces

Huella

Citar esto