High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Julio C. Osorio; Felipe Candia-Escobar; Alejandro H. Corvalán; Gloria M. Calaf; Francisco Aguayo

doi:10.3390/biology11121691

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Título traducido de la contribución: Infección por el virus del papiloma humano de alto riesgo en el cáncer de pulmón: Mecanismos y perspectivas

Julio C. Osorio
, Felipe Candia-Escobar
, Alejandro H. Corvalán
, Gloria M. Calaf
, Francisco Aguayo

Universidad de Chile
Pontificia Universidad Católica de Chile

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

14 Citas (Scopus)

Resumen

El cáncer de pulmón es un grupo de neoplasias malignas muy prevalente y heterogéneo, y la mayoría se asocia etiológicamente al tabaquismo. Sin embargo, se han detectado infecciones virales en carcinomas pulmonares, entre ellas los papilomavirus humanos de alto riesgo (VPH-AR). El papel de los VPH-AR en el cáncer de pulmón se considera controvertido. Esta controversia se debe a la gran variabilidad en la presencia de este virus en los carcinomas pulmonares a nivel mundial y a la baja carga viral que se detecta con frecuencia. En esta revisión, abordamos los hallazgos epidemiológicos y mecanísticos sobre el papel de los VPH-AR en el cáncer de pulmón. Se han propuesto algunos mecanismos de carcinogénesis pulmonar mediada por VPH-AR, entre ellos: (i) el VPH actúa como carcinógeno independiente en personas no fumadoras; (ii) el VPH interactúa con compuestos carcinógenos presentes en el humo del tabaco; (iii) el VPH promueve alteraciones iniciales que posteriormente son eliminadas por el sistema inmunitario mediante un mecanismo de «ataque y fuga». Se justifica realizar más investigaciones para esclarecer el papel del VPH en el cáncer de pulmón.

Título traducido de la contribución	Infección por el virus del papiloma humano de alto riesgo en el cáncer de pulmón: Mecanismos y perspectivas
Idioma original	Inglés
Número de artículo	1691
Publicación	Biology
Volumen	11
N.º	12
DOI	https://doi.org/10.3390/biology11121691
Estado	Publicada - 22 nov 2022

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Palabras clave

Cáncer
Pulmón
Papilomavirus

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10.3390/biology11121691Licencia: CC BY

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title = "High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives",

abstract = "Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.",

keywords = "cancer, lung, papillomavirus, C{\'a}ncer, Pulm{\'o}n, Papilomavirus",

author = "Osorio, \{Julio C.\} and Felipe Candia-Escobar and Corval{\'a}n, \{Alejandro H.\} and Calaf, \{Gloria M.\} and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = nov,

day = "22",

doi = "10.3390/biology11121691",

language = "English",

volume = "11",

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T1 - High-Risk Human Papillomavirus Infection in Lung Cancer

T2 - Mechanisms and Perspectives

AU - Osorio, Julio C.

AU - Candia-Escobar, Felipe

AU - Corvalán, Alejandro H.

AU - Calaf, Gloria M.

AU - Aguayo, Francisco

PY - 2022/11/22

Y1 - 2022/11/22

N2 - Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.

AB - Lung cancer is a very prevalent and heterogeneous group of malignancies, and most of them are etiologically associated with tobacco smoking. However, viral infections have been detected in lung carcinomas, with high-risk human papillomaviruses (HR-HPVs) being among them. The role of HR-HPVs in lung cancer has been considered to be controversial. This issue is due to the highly variable presence of this virus in lung carcinomas worldwide, and the low viral load frequently that is detected. In this review, we address the epidemiological and mechanistic findings regarding the role of HR-HPVs in lung cancer. Some mechanisms of HR-HPV-mediated lung carcinogenesis have been proposed, including (i) HPV works as an independent carcinogen in non-smoker subjects; (ii) HPV cooperates with carcinogenic compounds present in tobacco smoke; (iii) HPV promotes initial alterations being after cleared by the immune system through a “hit and run” mechanism. Additional research is warranted to clarify the role of HPV in lung cancer.

KW - cancer

KW - lung

KW - papillomavirus

KW - Cáncer

KW - Pulmón

KW - Papilomavirus

UR - https://www.scopus.com/pages/publications/85144930998

U2 - 10.3390/biology11121691

DO - 10.3390/biology11121691

M3 - Review article

AN - SCOPUS:85144930998

SN - 2079-7737

VL - 11

JO - Biology

JF - Biology

IS - 12

M1 - 1691

ER -

High-Risk Human Papillomavirus Infection in Lung Cancer: Mechanisms and Perspectives

Resumen

ODS de las Naciones Unidas

Palabras clave

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Huella

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