High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis

Francisco Aguayo; Juan P. Muñoz; Francisco Perez-Dominguez; Diego Carrillo-Beltrán; Carolina Oliva; Gloria M. Calaf; Rances Blanco; Daniela Nuñez-Acurio

doi:10.3390/cancers12082201

High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis

Título traducido de la contribución: Interacciones de alto riesgo entre el virus del papiloma humano y el humo del tabaco en la carcinogénesis epitelial

Francisco Aguayo
, Juan P. Muñoz
, Francisco Perez-Dominguez
, Diego Carrillo-Beltrán
, Carolina Oliva
, Gloria M. Calaf
, Rances Blanco
, Daniela Nuñez-Acurio

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

46 Citas (Scopus)

Resumen

Los cánceres de cuello uterino, anogenital y algunos de cabeza y cuello (CCC) están etiológicamente asociados con la infección por el virus del papiloma humano de alto riesgo (VPH-AR), aunque son necesarios cofactores adicionales. Estudios epidemiológicos han establecido que el humo de tabaco (TS) es un cofactor para la carcinogénesis cervical porque las mujeres que fuman son más susceptibles al cáncer cervical en comparación con las no fumadoras. Si bien dicha relación no se ha establecido en el CCC relacionado con el VPH, un grupo de pacientes VPH positivos con esta neoplasia maligna son fumadoras. El TS es una mezcla compleja de más de 4500 compuestos químicos y aproximadamente 60 de ellos muestran propiedades oncogénicas como el benzo[α]pireno (BaP) y las nitrosaminas, entre otros. Algunos de estos compuestos han sido evaluados para la carcinogénesis a través de entornos experimentales en colaboración con el VPH-AR. Aquí, realizamos una revisión exhaustiva de los mecanismos moleculares sugeridos involucrados en la cooperación tanto con el VPH-AR como con el TS para la carcinogénesis epitelial. Además, proponemos modelos de interacción en los que el TS colabora con el VPH-AR para promover la iniciación, la promoción y la progresión del cáncer epitelial. Se requieren más estudios para esclarecer las interacciones entre los virus oncogénicos y los factores ambientales químicos o físicos que contribuyen a la carcinogénesis epitelial.

Título traducido de la contribución	Interacciones de alto riesgo entre el virus del papiloma humano y el humo del tabaco en la carcinogénesis epitelial
Idioma original	Inglés
Número de artículo	2201
Páginas (desde-hasta)	1-18
Número de páginas	18
Publicación	Cancers
Volumen	12
N.º	8
DOI	https://doi.org/10.3390/cancers12082201
Estado	Publicada - 5 ago. 2020

Palabras clave

Cáncer
Cuello uterino
Virus del papiloma
Tabaquismo
Tabaco

ODS de las Naciones Unidas

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10.3390/cancers12082201Licencia: CC BY

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@article{c3cfc95e4e4b433e9642fcc978276fd2,

title = "High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis",

abstract = "Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have established that tobacco smoke (TS) is a cofactor for cervical carcinogenesis because women who smoke are more susceptible to cervical cancer when compared to non-smokers. Even though such a relationship has not been established in HPV-related HNC, a group of HPV positive patients with this malignancy are smokers. TS is a complex mixture of more than 4500 chemical compounds and approximately 60 of them show oncogenic properties such as benzo[α]pyrene (BaP) and nitrosamines, among others. Some of these compounds have been evaluated for carcinogenesis through experimental settings in collaboration with HR-HPV. Here, we conducted a comprehensive review of the suggested molecular mechanisms involved in cooperation with both HR-HPV and TS for epithelial carcinogenesis. Furthermore, we propose interaction models in which TS collaborates with HR-HPV to promote epithelial cancer initiation, promotion, and progression. More studies are warranted to clarify interactions between oncogenic viruses and chemical or physical environmental factors for epithelial carcinogenesis.",

keywords = "Cancer, Cervix, Papillomavirus, Smoking, Tobacco, C{\'a}ncer, Cuello uterino, Virus del papiloma, Tabaquismo, Tabaco",

author = "Francisco Aguayo and Mu{\~n}oz, \{Juan P.\} and Francisco Perez-Dominguez and Diego Carrillo-Beltr{\'a}n and Carolina Oliva and Calaf, \{Gloria M.\} and Rances Blanco and Daniela Nu{\~n}ez-Acurio",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = aug,

day = "5",

doi = "10.3390/cancers12082201",

language = "English",

volume = "12",

pages = "1--18",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

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TY - JOUR

T1 - High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis

AU - Aguayo, Francisco

AU - Muñoz, Juan P.

AU - Perez-Dominguez, Francisco

AU - Carrillo-Beltrán, Diego

AU - Oliva, Carolina

AU - Calaf, Gloria M.

AU - Blanco, Rances

AU - Nuñez-Acurio, Daniela

PY - 2020/8/5

Y1 - 2020/8/5

N2 - Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have established that tobacco smoke (TS) is a cofactor for cervical carcinogenesis because women who smoke are more susceptible to cervical cancer when compared to non-smokers. Even though such a relationship has not been established in HPV-related HNC, a group of HPV positive patients with this malignancy are smokers. TS is a complex mixture of more than 4500 chemical compounds and approximately 60 of them show oncogenic properties such as benzo[α]pyrene (BaP) and nitrosamines, among others. Some of these compounds have been evaluated for carcinogenesis through experimental settings in collaboration with HR-HPV. Here, we conducted a comprehensive review of the suggested molecular mechanisms involved in cooperation with both HR-HPV and TS for epithelial carcinogenesis. Furthermore, we propose interaction models in which TS collaborates with HR-HPV to promote epithelial cancer initiation, promotion, and progression. More studies are warranted to clarify interactions between oncogenic viruses and chemical or physical environmental factors for epithelial carcinogenesis.

AB - Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have established that tobacco smoke (TS) is a cofactor for cervical carcinogenesis because women who smoke are more susceptible to cervical cancer when compared to non-smokers. Even though such a relationship has not been established in HPV-related HNC, a group of HPV positive patients with this malignancy are smokers. TS is a complex mixture of more than 4500 chemical compounds and approximately 60 of them show oncogenic properties such as benzo[α]pyrene (BaP) and nitrosamines, among others. Some of these compounds have been evaluated for carcinogenesis through experimental settings in collaboration with HR-HPV. Here, we conducted a comprehensive review of the suggested molecular mechanisms involved in cooperation with both HR-HPV and TS for epithelial carcinogenesis. Furthermore, we propose interaction models in which TS collaborates with HR-HPV to promote epithelial cancer initiation, promotion, and progression. More studies are warranted to clarify interactions between oncogenic viruses and chemical or physical environmental factors for epithelial carcinogenesis.

KW - Cancer

KW - Cervix

KW - Papillomavirus

KW - Smoking

KW - Tobacco

KW - Cáncer

KW - Cuello uterino

KW - Virus del papiloma

KW - Tabaquismo

KW - Tabaco

UR - https://www.scopus.com/pages/publications/85090678520

U2 - 10.3390/cancers12082201

DO - 10.3390/cancers12082201

M3 - Review article

AN - SCOPUS:85090678520

SN - 2072-6694

VL - 12

SP - 1

EP - 18

JO - Cancers

JF - Cancers

IS - 8

M1 - 2201

ER -

High-risk human papillomavirus and tobacco smoke interactions in epithelial carcinogenesis

Resumen

Palabras clave

ODS de las Naciones Unidas

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