High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.

Rancés Blanco; Diego Carrillo-Beltrán; Corvalán Alejandro H.; Francisco Aguayo

doi:10.3390/biology10121232

High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.

Título traducido de la contribución: Coinfección por virus del papiloma humano de alto riesgo y virus de Epstein-Barr: un papel potencial en la carcinogénesis de cabeza y cuello.

Rancés Blanco
, Diego Carrillo-Beltrán
, Corvalán Alejandro H.
, Francisco Aguayo

Departamento de Ciencias Biomédicas

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

35 Citas (Scopus)

Resumen

Los virus del papiloma humano de alto riesgo (VPH-AR) y el virus de Epstein-Barr (VEB) son virus oncogénicos reconocidos que participan en el desarrollo de un subgrupo de cánceres de cabeza y cuello (CCC). Los VPH-AR se asocian etiológicamente con un subgrupo de carcinomas orofaríngeos (COF), mientras que el VEB es un agente etiológico reconocido de los carcinomas nasofaríngeos indiferenciados (CNF). En esta revisión, abordamos la evidencia epidemiológica y mecanística sobre una posible cooperación entre los VPH-AR y el VEB en el desarrollo de CCC. Considerando que: (1) tanto las infecciones por VPH-AR como por VEB requieren cofactores para la carcinogénesis; y (2) tanto el epitelio orofaríngeo como el oral pueden estar expuestos directamente a carcinógenos, como el alcohol o el humo del tabaco, planteamos la hipótesis de posibles mecanismos de interacción. La evidencia epidemiológica y experimental sugiere que la cooperación entre el VPH de alto riesgo y el VEB para el desarrollo de un subconjunto de cánceres de cabeza y cuello es plausible y justifica una mayor investigación.

Título traducido de la contribución	Coinfección por virus del papiloma humano de alto riesgo y virus de Epstein-Barr: un papel potencial en la carcinogénesis de cabeza y cuello.
Idioma original	Inglés
Número de artículo	1232
Publicación	Biology
Volumen	10
N.º	12
DOI	https://doi.org/10.3390/biology10121232
Estado	Publicada - 25 nov. 2021

Palabras clave

Virus de Epstein-Barr
Cáncer de cabeza y cuello
Virus del papiloma humano

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.3390/biology10121232Licencia: CC BY

Otros archivos y enlaces

Citar esto

@article{3f5eca55418b4c0083cbb7e1df5e1366,

title = "High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.",

abstract = "High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.",

keywords = "Virus de Epstein-Barr, C{\'a}ncer de cabeza y cuello, Virus del papiloma humano, Epstein–Barr virus, Head and neck cancer, Human papillomavirus",

author = "Ranc{\'e}s Blanco and Diego Carrillo-Beltr{\'a}n and \{Alejandro H.\}, Corval{\'a}n and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

day = "25",

doi = "10.3390/biology10121232",

language = "English",

volume = "10",

journal = "Biology",

issn = "2079-7737",

number = "12",

}

TY - JOUR

T1 - High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.

AU - Blanco, Rancés

AU - Carrillo-Beltrán, Diego

AU - Alejandro H., Corvalán

AU - Aguayo, Francisco

PY - 2021/11/25

Y1 - 2021/11/25

N2 - High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.

AB - High-risk human papillomaviruses (HR-HPVs) and Epstein–Barr virus (EBV) are recognized oncogenic viruses involved in the development of a subset of head and neck cancers (HNCs). HR-HPVs are etiologically associated with a subset of oropharyngeal carcinomas (OPCs), whereas EBV is a recognized etiological agent of undifferentiated nasopharyngeal carcinomas (NPCs). In this review, we address epidemiological and mechanistic evidence regarding a potential cooperation between HR-HPV and EBV for HNC development. Considering that: (1) both HR-HPV and EBV infections require cofactors for carcinogenesis; and (2) both oropharyngeal and oral epithelium can be directly exposed to carcinogens, such as alcohol or tobacco smoke, we hypothesize possible interaction mechanisms. The epidemiological and experimental evidence suggests that HR-HPV/EBV cooperation for developing a subset of HNCs is plausible and warrants further investigation.

KW - Virus de Epstein-Barr

KW - Cáncer de cabeza y cuello

KW - Virus del papiloma humano

KW - Epstein–Barr virus

KW - Head and neck cancer

KW - Human papillomavirus

UR - https://www.scopus.com/pages/publications/85120827484

UR - http://europepmc.org/abstract/med/34943147

U2 - 10.3390/biology10121232

DO - 10.3390/biology10121232

M3 - Review article

C2 - 34943147

SN - 2079-7737

VL - 10

JO - Biology

JF - Biology

IS - 12

M1 - 1232

ER -

High-Risk Human Papillomavirus and Epstein-Barr Virus Coinfection: A Potential Role in Head and Neck Carcinogenesis.

Resumen

Palabras clave

ODS de las Naciones Unidas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto