Genome-wide association study of long COVID

Macarena Fuentes-Guajardo; Fondazione COVID-19 Genomic Study (FOGS)

doi:10.1038/s41588-025-02100-w

Genome-wide association study of long COVID

Título traducido de la contribución: Estudio de asociación de todo el genoma de la COVID prolongada

Macarena Fuentes-Guajardo
, Fondazione COVID-19 Genomic Study (FOGS)

Departamento de Tecnología Médica

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

15 Citas (Scopus)

Resumen

Las infecciones pueden provocar síntomas y enfermedades persistentes, como herpes zóster tras varicela zóster o fiebre reumática tras infecciones estreptocócicas. De forma similar, la infección por el coronavirus 2 del síndrome respiratorio agudo severo (SARS‑CoV‑2) puede provocar la enfermedad por coronavirus prolongada (COVID), que se manifiesta típicamente como fatiga, síntomas pulmonares y disfunción cognitiva. Los mecanismos biológicos detrás de la COVID prolongada siguen sin estar claros. Realizamos un estudio de asociación de todo el genoma para la COVID prolongada, que incluyó hasta 6450 casos de COVID prolongada y 1 093 995 controles poblacionales de 24 estudios en 16 países. Descubrimos una asociación de FOXP4 con la COVID prolongada, independientemente de su asociación previamente identificada con la COVID-19 grave. La señal se replicó en 9500 casos de COVID prolongada y 798 835 controles poblacionales. Dado el papel del factor de transcripción FOXP4 en la fisiología y patología pulmonar, nuestros hallazgos destacan la importancia de la función pulmonar en la fisiopatología de la COVID prolongada.

Título traducido de la contribución	Estudio de asociación de todo el genoma de la COVID prolongada
Idioma original	Inglés
Páginas (desde-hasta)	1402-1417
Número de páginas	16
Publicación	Nature Genetics
Volumen	57
N.º	6
DOI	https://doi.org/10.1038/s41588-025-02100-w
Estado	Publicada - jun. 2025

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title = "Genome-wide association study of long COVID",

abstract = "Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4{\textquoteright}s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.",

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Genome-wide association study of long COVID

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