Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives

Julio C. Osorio; Rancés Blanco; Alejandro H. Corvalán; Juan P. Muñoz; Gloria M. Calaf; Francisco Aguayo

doi:10.3390/pathogens11020132

Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives

Título traducido de la contribución: Infección por el virus de Epstein-Barr en el cáncer de pulmón: Perspectivas y análisis

Julio C. Osorio
, Rancés Blanco
, Alejandro H. Corvalán
, Juan P. Muñoz
, Gloria M. Calaf
, Francisco Aguayo

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

14 Citas (Scopus)

Resumen

El cáncer de pulmón (CP) es la principal causa de muerte por cáncer en todo el mundo. El tabaquismo es el factor de riesgo más frecuente asociado etiológicamente al CP, aunque la exposición a otros factores ambientales como el arsénico, el radón o el asbesto también influye. Además, se ha sugerido la participación de algunas infecciones virales, como los virus del papiloma humano de alto riesgo (VPH-AR), el poliomavirus de células de Merkel (MCPyV), el retrovirus ovino Jaagsiekte (JSRV), el virus JC (JCV) y el virus de Epstein-Barr (VEB), en el CP, si bien aún no se ha establecido una relación etiológica. El VEB es un gammaherpesvirus ubicuo que causa infecciones persistentes y algunos tumores linfoides y epiteliales. Dado que el VEB se detecta de forma heterogénea en CP de diferentes partes del mundo, en esta revisión abordamos la evidencia epidemiológica y experimental de un posible papel del VEB. Considerando esta evidencia, proponemos mecanismos potencialmente implicados en la carcinogénesis pulmonar asociada al VEB. Se requieren estudios adicionales para analizar el papel del VEB en esta neoplasia maligna tan frecuente.

Título traducido de la contribución	Infección por el virus de Epstein-Barr en el cáncer de pulmón: Perspectivas y análisis
Idioma original	Inglés
Número de artículo	132
Publicación	Pathogens
Volumen	11
N.º	2
DOI	https://doi.org/10.3390/pathogens11020132
Estado	Publicada - 20 ene. 2022

Palabras clave

Cáncer
Virus de Epstein-Barr
Pulmón

ODS de las Naciones Unidas

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@article{b0be7abca9e146d6946bbbda4d33c13d,

title = "Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives",

abstract = "Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein– Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.",

keywords = "Cancer, Epstein–Barr virus, Lung, C{\'a}ncer, Virus de Epstein-Barr, Pulm{\'o}n",

author = "Osorio, \{Julio C.\} and Ranc{\'e}s Blanco and Corval{\'a}n, \{Alejandro H.\} and Mu{\~n}oz, \{Juan P.\} and Calaf, \{Gloria M.\} and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

day = "20",

doi = "10.3390/pathogens11020132",

language = "English",

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T1 - Epstein–Barr Virus Infection in Lung Cancer

T2 - Insights and Perspectives

AU - Osorio, Julio C.

AU - Blanco, Rancés

AU - Corvalán, Alejandro H.

AU - Muñoz, Juan P.

AU - Calaf, Gloria M.

AU - Aguayo, Francisco

PY - 2022/1/20

Y1 - 2022/1/20

N2 - Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein– Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.

AB - Lung cancer (LC) is the leading cause of cancer death worldwide. Tobacco smoke is the most frequent risk factor etiologically associated with LC, although exposures to other environmental factors such as arsenic, radon or asbestos are also involved. Additionally, the involvement of some viral infections such as high-risk human papillomaviruses (HR-HPVs), Merkel cell polyomavirus (MCPyV), Jaagsiekte Sheep Retrovirus (JSRV), John Cunningham Virus (JCV), and Epstein– Barr virus (EBV) has been suggested in LC, though an etiological relationship has not yet been established. EBV is a ubiquitous gamma herpesvirus causing persistent infections and some lymphoid and epithelial tumors. Since EBV is heterogeneously detected in LCs from different parts of the world, in this review we address the epidemiological and experimental evidence of a potential role of EBV. Considering this evidence, we propose mechanisms potentially involved in EBV-associated lung carcinogenesis. Additional studies are warranted to dissect the role of EBV in this very frequent malignancy.

KW - Cancer

KW - Epstein–Barr virus

KW - Lung

KW - Cáncer

KW - Virus de Epstein-Barr

KW - Pulmón

UR - https://www.scopus.com/pages/publications/85123237678

U2 - 10.3390/pathogens11020132

DO - 10.3390/pathogens11020132

M3 - Review article

AN - SCOPUS:85123237678

SN - 2076-0817

VL - 11

JO - Pathogens

JF - Pathogens

IS - 2

M1 - 132

ER -

Epstein–Barr Virus Infection in Lung Cancer: Insights and Perspectives

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Palabras clave

ODS de las Naciones Unidas

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