Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Claudia Arias-Calvachi; Rancés Blanco; Gloria M. Calaf; Francisco Aguayo

doi:10.3390/biology11060799

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Título traducido de la contribución: Asociación del virus de Epstein-Barr con el cáncer de mama: Evidencia y perspectivas

Claudia Arias-Calvachi
, Rancés Blanco
, Gloria M. Calaf
, Francisco Aguayo

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

15 Citas (Scopus)

Resumen

El virus de Epstein-Barr (VEB) es un virus de ADN con envoltura que pertenece a la familia Gamma Herpesviridae. Este virus establece una infección persistente latente/lítica, aunque puede estar implicado en el desarrollo de cáncer en algunos individuos. De hecho, existen evidencias que respaldan un papel etiológico del VEB en el carcinoma nasofaríngeo indiferenciado (CNF), un subtipo de carcinomas gástricos y linfomas. Además, se ha detectado VEB en carcinomas de mama (CM), si bien su función aún no se ha establecido. En esta revisión, resumimos la información epidemiológica sobre la presencia del VEB en el CM y proponemos modelos mecanísticos. Sin embargo, se requieren más estudios epidemiológicos y experimentales para confirmar estos modelos.

Título traducido de la contribución	Asociación del virus de Epstein-Barr con el cáncer de mama: Evidencia y perspectivas
Idioma original	Inglés
Número de artículo	799
Publicación	Biology
Volumen	11
N.º	6
DOI	https://doi.org/10.3390/biology11060799
Estado	Publicada - 23 may. 2022

Palabras clave

Cáncer de mama
Carcinogénesis
Virus de Epstein-Barr

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title = "Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives",

abstract = "Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.",

keywords = "Breast cancer, Carcinogenesis, Epstein–Barr virus, C{\'a}ncer de mama, Carcinog{\'e}nesis, Virus de Epstein-Barr",

author = "Claudia Arias-Calvachi and Ranc{\'e}s Blanco and Calaf, \{Gloria M.\} and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

day = "23",

doi = "10.3390/biology11060799",

language = "English",

volume = "11",

journal = "Biology",

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TY - JOUR

T1 - Epstein–Barr Virus Association with Breast Cancer

T2 - Evidence and Perspectives

AU - Arias-Calvachi, Claudia

AU - Blanco, Rancés

AU - Calaf, Gloria M.

AU - Aguayo, Francisco

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

AB - Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

KW - Breast cancer

KW - Carcinogenesis

KW - Epstein–Barr virus

KW - Cáncer de mama

KW - Carcinogénesis

KW - Virus de Epstein-Barr

UR - https://www.scopus.com/pages/publications/85131383699

U2 - 10.3390/biology11060799

DO - 10.3390/biology11060799

M3 - Review article

AN - SCOPUS:85131383699

SN - 2079-7737

VL - 11

JO - Biology

JF - Biology

IS - 6

M1 - 799

ER -

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

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