Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective

Alejandra Alarcón; Ursula Figueroa; Bastian Espinoza; Alejandra Sandoval; Gonzalo Carrasco-Aviño; Francisco R. Aguayo; Alejandro H. Corvalan

doi:10.5772/intechopen.70201

Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective

Título traducido de la contribución: Carcinoma gástrico asociado al virus de Epstein-Barr: La perspectiva de las Américas

Alejandra Alarcón
, Ursula Figueroa
, Bastian Espinoza
, Alejandra Sandoval
, Gonzalo Carrasco-Aviño
, Francisco R. Aguayo
, Alejandro H. Corvalan

Producción científica: Capítulo del libro/informe/acta de congreso › Capítulo › revisión exhaustiva

Resumen

La infección por el virus de Epstein-Barr (VEB) se ha asociado con diferentes neoplasias malignas, y evidencia contundente ha demostrado que puede tener un papel causal o, al menos, contribuyente a la carcinogénesis gástrica. Los cánceres gástricos asociados al VEB presentan una firma molecular única, que ha definido a este grupo de tumores como un subtipo molecular distintivo de cáncer gástrico. Este subtipo ha mostrado una mayor incidencia en América que en los países asiáticos. Este capítulo analiza los posibles factores subyacentes a estas diferencias y el papel emergente de la epigenética en la patogénesis del cáncer gástrico asociado al virus de Epstein-Barr.

Título traducido de la contribución	Carcinoma gástrico asociado al virus de Epstein-Barr: La perspectiva de las Américas
Idioma original	Inglés
Título de la publicación alojada	Gastric Cancer
Editores	Gyula Mozsik, Oszkár Karádi
Editorial	IntechOpen
Capítulo	2
ISBN (versión digital)	978-953-51-3528-9, 978-953-51-4645-2
ISBN (versión impresa)	978-953-51-3527-2
DOI	https://doi.org/10.5772/intechopen.70201
Estado	Publicada - 20 sep. 2017
Publicado de forma externa	Sí

Palabras clave

Cáncer gástrico
Virus de Epstein-Barr
Cepas
Diversidad filogeográfica
Anomalías epigenéticas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Acceder al documento

10.5772/intechopen.70201Licencia: CC BY

Citar esto

@inbook{9a89d2b4b0be4dd88c63f016d870e18c,

title = "Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas{\textquoteright} Perspective",

abstract = "Epstein-Barr virus (EBV) infection has been associated with different malignancies, and compelling evidence has shown that it may have a causative or at least contributing role in gastric carcinogenesis. EBV-associated gastric cancers have a unique molecular signature, which has defined this group of tumors as a distinctive molecular subtype of gastric cancer. This subtype has shown a greater incidence in the Americas than in the Asian countries. This chapter discusses about possible factors underlying these differences and the emerging roles of epigenetics in the pathogenesis of Epstein-Barr virus–associated gastric cancer.",

keywords = "C{\'a}ncer g{\'a}strico, Virus de Epstein-Barr, Cepas, Diversidad filogeogr{\'a}fica, Anomal{\'i}as epigen{\'e}ticas, Gastric cancer, Epstein-Barr virus, Strains, Phylogeographic diversity, Epigenetic abnormalities",

author = "Alejandra Alarc{\'o}n and Ursula Figueroa and Bastian Espinoza and Alejandra Sandoval and Gonzalo Carrasco-Avi{\~n}o and Aguayo, \{Francisco R.\} and Corvalan, \{Alejandro H.\}",

year = "2017",

month = sep,

day = "20",

doi = "10.5772/intechopen.70201",

language = "English",

isbn = "978-953-51-3527-2",

editor = "Gyula Mozsik and Oszk{\'a}r Kar{\'a}di",

booktitle = "Gastric Cancer",

publisher = "IntechOpen",

address = "United Kingdom",

}

TY - CHAP

T1 - Epstein-Barr Virus–Associated Gastric Carcinoma

T2 - The Americas’ Perspective

AU - Alarcón, Alejandra

AU - Figueroa, Ursula

AU - Espinoza, Bastian

AU - Sandoval, Alejandra

AU - Carrasco-Aviño, Gonzalo

AU - Aguayo, Francisco R.

AU - Corvalan, Alejandro H.

PY - 2017/9/20

Y1 - 2017/9/20

N2 - Epstein-Barr virus (EBV) infection has been associated with different malignancies, and compelling evidence has shown that it may have a causative or at least contributing role in gastric carcinogenesis. EBV-associated gastric cancers have a unique molecular signature, which has defined this group of tumors as a distinctive molecular subtype of gastric cancer. This subtype has shown a greater incidence in the Americas than in the Asian countries. This chapter discusses about possible factors underlying these differences and the emerging roles of epigenetics in the pathogenesis of Epstein-Barr virus–associated gastric cancer.

AB - Epstein-Barr virus (EBV) infection has been associated with different malignancies, and compelling evidence has shown that it may have a causative or at least contributing role in gastric carcinogenesis. EBV-associated gastric cancers have a unique molecular signature, which has defined this group of tumors as a distinctive molecular subtype of gastric cancer. This subtype has shown a greater incidence in the Americas than in the Asian countries. This chapter discusses about possible factors underlying these differences and the emerging roles of epigenetics in the pathogenesis of Epstein-Barr virus–associated gastric cancer.

KW - Cáncer gástrico

KW - Virus de Epstein-Barr

KW - Cepas

KW - Diversidad filogeográfica

KW - Anomalías epigenéticas

KW - Gastric cancer

KW - Epstein-Barr virus

KW - Strains

KW - Phylogeographic diversity

KW - Epigenetic abnormalities

U2 - 10.5772/intechopen.70201

DO - 10.5772/intechopen.70201

M3 - Chapter

SN - 978-953-51-3527-2

BT - Gastric Cancer

A2 - Mozsik, Gyula

A2 - Karádi, Oszkár

PB - IntechOpen

ER -

Epstein-Barr Virus–Associated Gastric Carcinoma: The Americas’ Perspective

Resumen

Palabras clave

ODS de las Naciones Unidas

Acceder al documento

Huella

Citar esto