TY - JOUR
T1 - Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles
T2 - Effect of Doping Concentration
AU - Gnaneswari, M. Divya
AU - Raghavan, C.
AU - Chandrasekar, L. Bruno
AU - Karunakaran, M.
AU - Saravanan, L.
AU - Vimal, S.
AU - Rajendran, Saravanan
AU - Mohandoss, Sonaimuthu
AU - Palanisamy, Subramanian
AU - Thirumalai, J.
AU - Sundaram, P. Shunmuga
N1 - Publisher Copyright:
© Allerton Press, Inc. 2025.
PY - 2025/8
Y1 - 2025/8
N2 - Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.
AB - Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.
KW - MTT assay
KW - Vanadium
KW - apoptosis
KW - colon cancer
KW - septicemia
UR - https://www.scopus.com/pages/publications/105016718636
U2 - 10.3103/S1068335625602535
DO - 10.3103/S1068335625602535
M3 - Article
AN - SCOPUS:105016718636
SN - 1068-3356
VL - 52
SP - 395
EP - 408
JO - Bulletin of the Lebedev Physics Institute
JF - Bulletin of the Lebedev Physics Institute
IS - 8
ER -
