EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.

Keila Torres; Natalia Landeros; Ignacio A. Wichmann; Iva Polakovicova; Francisco Aguayo; Alejandro H. Corvalan

doi:10.1016/j.bbadis.2020.166049

EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.

Título traducido de la contribución: miR-BART de EBV y lncRNA humanos: cambiando el equilibrio en las redes de ARN endógeno en competencia en el cáncer gástrico asociado al EBV.

Keila Torres
, Natalia Landeros
, Ignacio A. Wichmann
, Iva Polakovicova
, Francisco Aguayo
, Alejandro H. Corvalan

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

16 Citas (Scopus)

Resumen

Los ARN no codificantes (ARNnc) contribuyen a la regulación de la expresión génica. Al actuar como ARN endógeno competidor (ARNce), los ARN no codificantes largos (ARNlnc) secuestran microARN (miARN) e inhiben su capacidad para unirse a sus dianas codificantes. Los miARN virales pueden competir con los mismos transcritos que los miARN humanos y dirigirse a ellos, alterando así el equilibrio en las redes asociadas con múltiples procesos y enfermedades celulares. El virus de Epstein-Barr (VEB) es un ejemplo de cómo un subconjunto de ARN codificante y ARN no codificante viral puede causar la desregulación de los transcritos humanos y contribuir al desarrollo de neoplasias malignas asociadas al VEB. Los genes transformantes no codificantes del VEB incluyen los ARNlnc (ARN circulares) y los ARNnc pequeños (miARN). Entre estos últimos, la mayor parte de la investigación en curso se ha centrado en los miR-BART, que se dirigen a muchos genes asociados con la apoptosis y la transición epitelial-mesenquimal en el cáncer gástrico (CG) asociado al VEB. En esta revisión, proponemos incluir las interacciones entre los ARNnc del VEB y las transcripciones humanas en la hipótesis conocida como «ARN virales y del huésped competitivos». Estas interacciones podrían alterar el equilibrio en vías biológicas como la apoptosis y la transición epitelio-mesenquimal en el cáncer gástrico asociado al VEB.

Título traducido de la contribución	miR-BART de EBV y lncRNA humanos: cambiando el equilibrio en las redes de ARN endógeno en competencia en el cáncer gástrico asociado al EBV.
Idioma original	Inglés
Número de artículo	166049
Publicación	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volumen	1867
N.º	4
DOI	https://doi.org/10.1016/j.bbadis.2020.166049
Estado	Publicada - 1 abr. 2021
Publicado de forma externa	Sí

Palabras clave

Apoptosis
ARN virales y del huésped competitivos
Cáncer gástrico asociado al virus de Epstein-Barr (VEB)
Transición epitelial a mesenquimal
ARN largo no codificante
miR-BART

ODS de las Naciones Unidas

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10.1016/j.bbadis.2020.166049

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@article{ec400dd3904d47228e464c33866785a3,

title = "EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.",

abstract = "Non-coding RNAs (ncRNAs) contribute to the regulation of gene expression. By acting as competing endogenous RNA (ceRNA), long non-coding RNAs (lncRNAs) hijack microRNAs (miRNAs) and inhibit their ability to bind their coding targets. Viral miRNAs can compete with and target the same transcripts as human miRNAs, shifting the balance in networks associated with multiple cellular processes and diseases. Epstein-Barr virus (EBV) is an example of how a subset of viral coding RNA and non-coding RNAs can cause deregulation of human transcripts and contribute to the development of EBV-associated malignancies. EBV non-coding transforming genes include lncRNAs (i.e circular RNAs), and small ncRNAs (i.e. miRNAs). Among the latter, most ongoing research has focused on miR-BARTs whereas target many genes associated with apoptosis and epithelial-mesenchymal transition, in EBV-associated gastric cancer (GC). In this review, we propose to include the interactions between EBV ncRNAs human transcripts in the hypothesis known as “competitive viral and host RNAs”. These interactions may shift the balance in biological pathways such as apoptosis and epithelial-mesenchymal transition in EBV-associated gastric cancer.",

keywords = "Apoptosis, ARN virales y del hu{\'e}sped competitivos, C{\'a}ncer g{\'a}strico asociado al virus de Epstein-Barr (VEB), Transici{\'o}n epitelial a mesenquimal, ARN largo no codificante, miR-BART, Apoptosis, Competitive viral and host RNAs, EBV-associated gastric cancer, Epithelial to mesenchymal transition, Long non-coding, miR-BARTs",

author = "Keila Torres and Natalia Landeros and Wichmann, \{Ignacio A.\} and Iva Polakovicova and Francisco Aguayo and Corvalan, \{Alejandro H.\}",

year = "2021",

month = apr,

day = "1",

doi = "10.1016/j.bbadis.2020.166049",

language = "English",

volume = "1867",

journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",

issn = "0925-4439",

publisher = "Elsevier",

number = "4",

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EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer. / Torres, Keila; Landeros, Natalia; Wichmann, Ignacio A. et al.
En: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1867, N.º 4, 166049, 01.04.2021.

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

TY - JOUR

T1 - EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.

AU - Torres, Keila

AU - Landeros, Natalia

AU - Wichmann, Ignacio A.

AU - Polakovicova, Iva

AU - Aguayo, Francisco

AU - Corvalan, Alejandro H.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Non-coding RNAs (ncRNAs) contribute to the regulation of gene expression. By acting as competing endogenous RNA (ceRNA), long non-coding RNAs (lncRNAs) hijack microRNAs (miRNAs) and inhibit their ability to bind their coding targets. Viral miRNAs can compete with and target the same transcripts as human miRNAs, shifting the balance in networks associated with multiple cellular processes and diseases. Epstein-Barr virus (EBV) is an example of how a subset of viral coding RNA and non-coding RNAs can cause deregulation of human transcripts and contribute to the development of EBV-associated malignancies. EBV non-coding transforming genes include lncRNAs (i.e circular RNAs), and small ncRNAs (i.e. miRNAs). Among the latter, most ongoing research has focused on miR-BARTs whereas target many genes associated with apoptosis and epithelial-mesenchymal transition, in EBV-associated gastric cancer (GC). In this review, we propose to include the interactions between EBV ncRNAs human transcripts in the hypothesis known as “competitive viral and host RNAs”. These interactions may shift the balance in biological pathways such as apoptosis and epithelial-mesenchymal transition in EBV-associated gastric cancer.

AB - Non-coding RNAs (ncRNAs) contribute to the regulation of gene expression. By acting as competing endogenous RNA (ceRNA), long non-coding RNAs (lncRNAs) hijack microRNAs (miRNAs) and inhibit their ability to bind their coding targets. Viral miRNAs can compete with and target the same transcripts as human miRNAs, shifting the balance in networks associated with multiple cellular processes and diseases. Epstein-Barr virus (EBV) is an example of how a subset of viral coding RNA and non-coding RNAs can cause deregulation of human transcripts and contribute to the development of EBV-associated malignancies. EBV non-coding transforming genes include lncRNAs (i.e circular RNAs), and small ncRNAs (i.e. miRNAs). Among the latter, most ongoing research has focused on miR-BARTs whereas target many genes associated with apoptosis and epithelial-mesenchymal transition, in EBV-associated gastric cancer (GC). In this review, we propose to include the interactions between EBV ncRNAs human transcripts in the hypothesis known as “competitive viral and host RNAs”. These interactions may shift the balance in biological pathways such as apoptosis and epithelial-mesenchymal transition in EBV-associated gastric cancer.

KW - Apoptosis

KW - ARN virales y del huésped competitivos

KW - Cáncer gástrico asociado al virus de Epstein-Barr (VEB)

KW - Transición epitelial a mesenquimal

KW - ARN largo no codificante

KW - miR-BART

KW - Apoptosis

KW - Competitive viral and host RNAs

KW - EBV-associated gastric cancer

KW - Epithelial to mesenchymal transition

KW - Long non-coding

KW - miR-BARTs

UR - https://www.scopus.com/pages/publications/85098986919

U2 - 10.1016/j.bbadis.2020.166049

DO - 10.1016/j.bbadis.2020.166049

M3 - Review article

C2 - 33401001

SN - 0925-4439

VL - 1867

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 4

M1 - 166049

ER -

EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer.

Resumen

Palabras clave

ODS de las Naciones Unidas

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