Dendrimers: Amazing platforms for bioactive molecule delivery systems

Claudia Sandoval-Yañez; Cristian Castro Rodriguez

doi:10.3390/ma13030570

Dendrimers: Amazing platforms for bioactive molecule delivery systems

Claudia Sandoval-Yañez
, Cristian Castro Rodriguez

Departamento de Química

Universidad Autónoma de Chile

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

112 Citas (Scopus)

Resumen

Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

Idioma original	Inglés
Número de artículo	570
Publicación	Materials
Volumen	13
N.º	3
DOI	https://doi.org/10.3390/ma13030570
Estado	Publicada - 1 feb. 2020

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title = "Dendrimers: Amazing platforms for bioactive molecule delivery systems",

abstract = "Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.",

keywords = "Bioactive molecules, Cancer disease, Cardiovascular disease, Dendrimers, Drug delivery systems",

author = "Claudia Sandoval-Ya{\~n}ez and Rodriguez, \{Cristian Castro\}",

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N2 - Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

AB - Today, dendrimers are the main nanoparticle applied to drug delivery systems. The physicochemical characteristics of dendrimers and their versatility structural modification make them attractive to applied as a platform to bioactive molecules transport. Nanoformulations based on dendrimers enhance low solubility drugs, arrival to the target tissue, drugs bioavailability, and controlled release. This review describes the latter approaches on the transport of bioactive molecules based on dendrimers. The review focus is on the last therapeutic strategies addressed by dendrimers conjugated with bioactive molecules. A brief review of the latest studies in therapies against cancer and cardiovascular diseases, as well as future projections in the area, are addressed.

KW - Bioactive molecules

KW - Cancer disease

KW - Cardiovascular disease

KW - Dendrimers

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UR - https://www.scopus.com/pages/publications/85079276272

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JO - Materials

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ER -

Dendrimers: Amazing platforms for bioactive molecule delivery systems

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