TY - JOUR
T1 - A critical review on the use of potentiometric based biosensors for biomarkers detection
AU - Karimi-Maleh, Hassan
AU - Orooji, Yasin
AU - Karimi, Fatemeh
AU - Alizadeh, Marzieh
AU - Baghayeri, Mehdi
AU - Rouhi, Jalal
AU - Tajik, Somayeh
AU - Beitollahi, Hadi
AU - Agarwal, Shilpi
AU - Gupta, Vinod K.
AU - Rajendran, Saravanan
AU - Ayati, Ali
AU - Fu, Li
AU - Sanati, Afsaneh L.
AU - Tanhaei, Bahareh
AU - Sen, Fatih
AU - shabani-nooshabadi, Mehdi
AU - Asrami, Padideh Naderi
AU - Al-Othman, Amani
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/7/15
Y1 - 2021/7/15
N2 - Potentiometric-based biosensors have the potential to advance the detection of several biological compounds and help in early diagnosis of various diseases. They belong to the portable analytical class of biosensors for monitoring biomarkers in the human body. They contain ion-sensitive membranes sensors can be used to determine potassium, sodium, and chloride ions activity while being used as a biomarker to gauge human health. The potentiometric based ion-sensitive membrane systems can be coupled with various techniques to create a sensitive tool for the fast and early detection of cancer biomarkers and other critical biological compounds. This paper discusses the application of potentiometric-based biosensors and classifies them into four major categories: photoelectrochemical potentiometric biomarkers, potentiometric biosensors amplified with molecular imprinted polymer systems, wearable potentiometric biomarkers and light-addressable potentiometric biosensors. This review demonstrated the development of several innovative biosensor-based techniques that could potentially provide reliable tools to test biomarkers. Some challenges however remain, but these can be removed by coupling techniques to maximize the testing sensitivity.
AB - Potentiometric-based biosensors have the potential to advance the detection of several biological compounds and help in early diagnosis of various diseases. They belong to the portable analytical class of biosensors for monitoring biomarkers in the human body. They contain ion-sensitive membranes sensors can be used to determine potassium, sodium, and chloride ions activity while being used as a biomarker to gauge human health. The potentiometric based ion-sensitive membrane systems can be coupled with various techniques to create a sensitive tool for the fast and early detection of cancer biomarkers and other critical biological compounds. This paper discusses the application of potentiometric-based biosensors and classifies them into four major categories: photoelectrochemical potentiometric biomarkers, potentiometric biosensors amplified with molecular imprinted polymer systems, wearable potentiometric biomarkers and light-addressable potentiometric biosensors. This review demonstrated the development of several innovative biosensor-based techniques that could potentially provide reliable tools to test biomarkers. Some challenges however remain, but these can be removed by coupling techniques to maximize the testing sensitivity.
KW - Biomarkers
KW - Light-addressable systems
KW - Molecularly imprinted polymers
KW - Photoelectrochemical
KW - Potentiometric systems
KW - Wearable systems
UR - https://www.scopus.com/pages/publications/85105338003
U2 - 10.1016/j.bios.2021.113252
DO - 10.1016/j.bios.2021.113252
M3 - Review article
C2 - 33895688
AN - SCOPUS:85105338003
SN - 0956-5663
VL - 184
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 113252
ER -
