PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Francisco Aguayo; Francisco Perez-Dominguez; Julio C. Osorio; Carolina Oliva; Gloria M. Calaf

doi:10.3390/biology12050672

PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Translated title of the contribution: PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Francisco Aguayo
, Francisco Perez-Dominguez
, Julio C. Osorio
, Carolina Oliva
, Gloria M. Calaf

Universidad de Chile

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.

Translated title of the contribution	PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications
Original language	English
Article number	672
Journal	Biology
Volume	12
Issue number	5
DOIs	https://doi.org/10.3390/biology12050672
State	Published - 28 Apr 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
oropharyngeal
PI3K/Akt

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10.3390/biology12050672

Cite this

@article{01242861a2d0453a8e587008f0d9c3a9,

title = "PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications",

abstract = "High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.",

keywords = "cancer, oropharyngeal, PI3K/Akt, C{\'a}ncer, Orofar{\'i}ngeo, PI3K/Akt",

author = "Francisco Aguayo and Francisco Perez-Dominguez and Osorio, \{Julio C.\} and Carolina Oliva and Calaf, \{Gloria M.\}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = apr,

day = "28",

doi = "10.3390/biology12050672",

language = "English",

volume = "12",

journal = "Biology",

issn = "2079-7737",

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}

TY - JOUR

T1 - PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis

T2 - Therapeutic Implications

AU - Aguayo, Francisco

AU - Perez-Dominguez, Francisco

AU - Osorio, Julio C.

AU - Oliva, Carolina

AU - Calaf, Gloria M.

PY - 2023/4/28

Y1 - 2023/4/28

N2 - High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.

AB - High-risk human papillomaviruses (HR-HPVs) are the causal agents of cervical, anogenital and a subset of head and neck carcinomas (HNCs). Indeed, oropharyngeal cancers are a type of HNC highly associated with HR-HPV infections and constitute a specific clinical entity. The oncogenic mechanism of HR-HPV involves E6/E7 oncoprotein overexpression for promoting cell immortalization and transformation, through the downregulation of p53 and pRB tumor suppressor proteins, among other cellular targets. Additionally, E6/E7 proteins are involved in promoting PI3K/AKT/mTOR signaling pathway alterations. In this review, we address the relationship between HR-HPV and PI3K/AKT/mTOR signaling pathway activation in HNC with an emphasis on its therapeutic importance.

KW - cancer

KW - oropharyngeal

KW - PI3K/Akt

KW - Cáncer

KW - Orofaríngeo

KW - PI3K/Akt

UR - https://www.scopus.com/pages/publications/85160301002

U2 - 10.3390/biology12050672

DO - 10.3390/biology12050672

M3 - Review article

AN - SCOPUS:85160301002

SN - 2079-7737

VL - 12

JO - Biology

JF - Biology

IS - 5

M1 - 672

ER -

PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications

Abstract

UN SDGs

Keywords

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