Abstract
Breast, cervical and ovarian cancers are highly prevalent in women worldwide. Environmental, hormonal and viral-related factors are especially relevant in the development of these tumors. These factors are strongly related to oxidative stress (OS) through the generation of reactive oxygen species (ROS). The OS is caused by an imbalance in the redox status of the organism and is literally defined as "an imbalance between ROS generation and its detoxification by biological system leading to impairment of damage repair by cell/tissue". The multistep progression of cancer suggests that OS is involved in cancer initiation, promotion and progression. In this review, we described the role of OS and the interplay with environmental, host and viral factors related to breast, cervical and ovarian cancers initiation, promotion and progression. In addition, the role of the natural antioxidant compound curcumin and other compounds for breast, cervical and ovarian cancers prevention/treatment is discussed.
| Translated title of the contribution | Oxidative stress in female cancers |
|---|---|
| Original language | English |
| Pages (from-to) | 23824-23842 |
| Number of pages | 19 |
| Journal | Oncotarget |
| Volume | 9 |
| Issue number | 34 |
| DOIs | |
| State | Published - 4 May 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Breast
- Cervical
- Curcumin
- Ovarian cancer
- Oxidative stress
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