Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Rita Nahta; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Rafaela Andrade-Vieira; Sarah Bay; Dustin G. Brown; Gloria M. Calaf; Robert C. Castellino; Karine A. Cohen-Solal; Annamaria Colacci; Nichola Cruickshanks; Paul Dent; Riccardo Di Fiore; Stefano Forte; Gary S. Goldberg; Roslida A. Hamid; Harini Krishnan; Dale W. Laird; Ahmed Lasfar; Paola A. Marignani; Lorenzo Memeo; Chiara Mondello; Christian C. Naus; Richard Ponce-Cusi; Jayadev Raju; Debasish Roy; Rabindra Roy; Elizabeth P. Ryan; Hosni K. Salem; A. Ivana Scovassi; Neetu Singh; Monica Vaccari; Renza Vento; Jan Vondráček; Mark Wade; Jordan Woodrick; William H. Bisson

doi:10.1093/carcin/bgv028

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Rita Nahta
, Fahd Al-Mulla
, Rabeah Al-Temaimi
, Amedeo Amedei
, Rafaela Andrade-Vieira
, Sarah Bay
, Dustin G. Brown
, Gloria M. Calaf
, Robert C. Castellino
, Karine A. Cohen-Solal
, Annamaria Colacci
, Nichola Cruickshanks
, Paul Dent
, Riccardo Di Fiore
, Stefano Forte
, Gary S. Goldberg
, Roslida A. Hamid
, Harini Krishnan
, Dale W. Laird
, Ahmed Lasfar

Paola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A. Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondráček, Mark Wade, Jordan Woodrick, William H. Bisson

Institute of Higher Research

Emory University
Kuwait University
University of Florence
Dalhousie University
Colorado State University
Columbia University
Rutgers - The State University of New Jersey, New Brunswick
Envirn. Protection
Virginia Commonwealth University
University of Palermo
Mediterranean Institute of Oncology
Rowan University
University Putra
Western University
National Research Council of Italy
University of British Columbia
Universidad de Tarapacá
Health Canada
City University of New York
Georgetown University
Cairo University
King George's Medical University
Temple University
Institute of Biophysics AS CR
Italian Institute of Technology
Oregon State University

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

Original language	English
Pages (from-to)	S2-S18
Journal	Carcinogenesis
Volume	36
DOIs	https://doi.org/10.1093/carcin/bgv028
State	Published - 1 Jun 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1093/carcin/bgv028

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Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei, A., Andrade-Vieira, R., Bay, S., Brown, D. G., Calaf, G. M., Castellino, R. C., Cohen-Solal, K. A., Colacci, A., Cruickshanks, N., Dent, P., Di Fiore, R., Forte, S., Goldberg, G. S., Hamid, R. A., Krishnan, H., Laird, D. W., ... Bisson, W. H. (2015). Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis, 36, S2-S18. https://doi.org/10.1093/carcin/bgv028

@article{7a6c2cac408641c287e8d41727983cd0,

title = "Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression",

abstract = "As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.",

author = "Rita Nahta and Fahd Al-Mulla and Rabeah Al-Temaimi and Amedeo Amedei and Rafaela Andrade-Vieira and Sarah Bay and Brown, \{Dustin G.\} and Calaf, \{Gloria M.\} and Castellino, \{Robert C.\} and Cohen-Solal, \{Karine A.\} and Annamaria Colacci and Nichola Cruickshanks and Paul Dent and \{Di Fiore\}, Riccardo and Stefano Forte and Goldberg, \{Gary S.\} and Hamid, \{Roslida A.\} and Harini Krishnan and Laird, \{Dale W.\} and Ahmed Lasfar and Marignani, \{Paola A.\} and Lorenzo Memeo and Chiara Mondello and Naus, \{Christian C.\} and Richard Ponce-Cusi and Jayadev Raju and Debasish Roy and Rabindra Roy and Ryan, \{Elizabeth P.\} and Salem, \{Hosni K.\} and \{Ivana Scovassi\}, A. and Neetu Singh and Monica Vaccari and Renza Vento and Jan Vondr{\'a}{\v c}ek and Mark Wade and Jordan Woodrick and Bisson, \{William H.\}",

note = "Publisher Copyright: {\textcopyright} The Author 2015.",

year = "2015",

month = jun,

day = "1",

doi = "10.1093/carcin/bgv028",

language = "English",

volume = "36",

pages = "S2--S18",

journal = "Carcinogenesis",

issn = "0143-3334",

}

Nahta, R, Al-Mulla, F, Al-Temaimi, R, Amedei, A, Andrade-Vieira, R, Bay, S, Brown, DG, Calaf, GM, Castellino, RC, Cohen-Solal, KA, Colacci, A, Cruickshanks, N, Dent, P, Di Fiore, R, Forte, S, Goldberg, GS, Hamid, RA, Krishnan, H, Laird, DW, Lasfar, A, Marignani, PA, Memeo, L, Mondello, C, Naus, CC, Ponce-Cusi, R, Raju, J, Roy, D, Roy, R, Ryan, EP, Salem, HK, Ivana Scovassi, A, Singh, N, Vaccari, M, Vento, R, Vondráček, J, Wade, M, Woodrick, J & Bisson, WH 2015, 'Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression', Carcinogenesis, vol. 36, pp. S2-S18. https://doi.org/10.1093/carcin/bgv028

TY - JOUR

T1 - Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

AU - Nahta, Rita

AU - Al-Mulla, Fahd

AU - Al-Temaimi, Rabeah

AU - Amedei, Amedeo

AU - Andrade-Vieira, Rafaela

AU - Bay, Sarah

AU - Brown, Dustin G.

AU - Calaf, Gloria M.

AU - Castellino, Robert C.

AU - Cohen-Solal, Karine A.

AU - Colacci, Annamaria

AU - Cruickshanks, Nichola

AU - Dent, Paul

AU - Di Fiore, Riccardo

AU - Forte, Stefano

AU - Goldberg, Gary S.

AU - Hamid, Roslida A.

AU - Krishnan, Harini

AU - Laird, Dale W.

AU - Lasfar, Ahmed

AU - Marignani, Paola A.

AU - Memeo, Lorenzo

AU - Mondello, Chiara

AU - Naus, Christian C.

AU - Ponce-Cusi, Richard

AU - Raju, Jayadev

AU - Roy, Debasish

AU - Roy, Rabindra

AU - Ryan, Elizabeth P.

AU - Salem, Hosni K.

AU - Ivana Scovassi, A.

AU - Singh, Neetu

AU - Vaccari, Monica

AU - Vento, Renza

AU - Vondráček, Jan

AU - Wade, Mark

AU - Woodrick, Jordan

AU - Bisson, William H.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

AB - As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.

UR - https://www.scopus.com/pages/publications/84937697813

U2 - 10.1093/carcin/bgv028

DO - 10.1093/carcin/bgv028

M3 - Review article

C2 - 26106139

AN - SCOPUS:84937697813

SN - 0143-3334

VL - 36

SP - S2-S18

JO - Carcinogenesis

JF - Carcinogenesis

ER -

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Abstract

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