Intratask variability as a correlate for DRD4 and SLC6A3 variants: A pilot study in ADHD

Marcela Henríquez-Henríquez; Luis Villarroel; Hugo Henríquez; Francisco Zamorano; Francisco Rothhammer; Francisco Aboitiz

doi:10.1177/1087054712455844

Intratask variability as a correlate for DRD4 and SLC6A3 variants: A pilot study in ADHD

Marcela Henríquez-Henríquez
, Luis Villarroel
, Hugo Henríquez
, Francisco Zamorano
, Francisco Rothhammer
, Francisco Aboitiz

Institute of Higher Research

Pontificia Universidad Católica de Chile
Universidad Mayor

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.

Original language	English
Pages (from-to)	987-996
Number of pages	10
Journal	Journal of Attention Disorders
Volume	19
Issue number	11
DOIs	https://doi.org/10.1177/1087054712455844
State	Published - Nov 2015

Keywords

ADHD
Genetic variants
Within-subject variability

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10.1177/1087054712455844

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title = "Intratask variability as a correlate for DRD4 and SLC6A3 variants: A pilot study in ADHD",

abstract = "Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10\% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.",

keywords = "ADHD, Genetic variants, Within-subject variability",

author = "Marcela Henr{\'i}quez-Henr{\'i}quez and Luis Villarroel and Hugo Henr{\'i}quez and Francisco Zamorano and Francisco Rothhammer and Francisco Aboitiz",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2012.",

year = "2015",

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doi = "10.1177/1087054712455844",

language = "English",

volume = "19",

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T2 - A pilot study in ADHD

AU - Henríquez-Henríquez, Marcela

AU - Villarroel, Luis

AU - Henríquez, Hugo

AU - Zamorano, Francisco

AU - Rothhammer, Francisco

AU - Aboitiz, Francisco

N1 - Publisher Copyright: © The Author(s) 2012.

PY - 2015/11

Y1 - 2015/11

N2 - Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.

AB - Behavioral variability may be an ADHD key feature. Currently used ex-Gaussian/Fast Fourier Transform analyses characterize general distribution and oscillatory/rhythmic components of performance but are unable to demonstrate slow cumulative changes over entire tasks. Objective: To explore how performance of ADHD children and unaffected sibs gradually evolves in relation to genetic variants linked to ADHD. Method: A total of 40 kids (20 ADHD-discordant sib pairs) between 8 and 13 years resolved a visual Go/NoGo with 10% NoGo probability. Variable number tandem repeats (VNTRs) at DRD4 and SLC6A3 were identified following standard protocols. Performance changes were assessed by linear/logistic mixedeffect models. Results: Models exploring SLC6A3 effects demonstrated less accentuated increments of response time (RT) (p =.046) and cumulative increments in the correct responses to “NoGo” (p =.00027) in 10R/10R participants. Models for DRD4 showed faster decline of correct responses to “Go” (p =.0078) in 2R/7R carriers. Conclusion: Dynamical analysis of attention/ inhibition measures may unravel new correlates to DRD4 and SLC6A3 variants.

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KW - Genetic variants

KW - Within-subject variability

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JO - Journal of Attention Disorders

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IS - 11

ER -

Intratask variability as a correlate for DRD4 and SLC6A3 variants: A pilot study in ADHD

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