HLA Antigens in cardiomyopathic Chilean chagasics

E. Llop; F. Rothhammer; M. Acuna; W. Apt

HLA Antigens in cardiomyopathic Chilean chagasics

E. Llop
, F. Rothhammer
, M. Acuna
, W. Apt

Universidad de Chile

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The distribution of HLA antigens in a sample of 124 Chagas serologically positive Chilean individuals was studied. The sample was subdivided according to the presence or absence of chagasic cardiomyopathy, in order to search for genetic differences associated with this pathological condition. The frequency of antigen B40 in the presence of antigen Cw3 was found to be significantly lower in subjects with cardiomyopathy. We tentatively suggest that the presence of these antigens noncardiomyopathics is associated with a decreased susceptibility to develop chagasic cardiomyopathy in the Chilean population.

Original language	English
Pages (from-to)	770-773
Number of pages	4
Journal	American Journal of Human Genetics
Volume	43
Issue number	5
State	Published - 1988
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "HLA Antigens in cardiomyopathic Chilean chagasics",

abstract = "The distribution of HLA antigens in a sample of 124 Chagas serologically positive Chilean individuals was studied. The sample was subdivided according to the presence or absence of chagasic cardiomyopathy, in order to search for genetic differences associated with this pathological condition. The frequency of antigen B40 in the presence of antigen Cw3 was found to be significantly lower in subjects with cardiomyopathy. We tentatively suggest that the presence of these antigens noncardiomyopathics is associated with a decreased susceptibility to develop chagasic cardiomyopathy in the Chilean population.",

author = "E. Llop and F. Rothhammer and M. Acuna and W. Apt",

year = "1988",

language = "English",

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journal = "American Journal of Human Genetics",

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T1 - HLA Antigens in cardiomyopathic Chilean chagasics

AU - Llop, E.

AU - Rothhammer, F.

AU - Acuna, M.

AU - Apt, W.

PY - 1988

Y1 - 1988

N2 - The distribution of HLA antigens in a sample of 124 Chagas serologically positive Chilean individuals was studied. The sample was subdivided according to the presence or absence of chagasic cardiomyopathy, in order to search for genetic differences associated with this pathological condition. The frequency of antigen B40 in the presence of antigen Cw3 was found to be significantly lower in subjects with cardiomyopathy. We tentatively suggest that the presence of these antigens noncardiomyopathics is associated with a decreased susceptibility to develop chagasic cardiomyopathy in the Chilean population.

AB - The distribution of HLA antigens in a sample of 124 Chagas serologically positive Chilean individuals was studied. The sample was subdivided according to the presence or absence of chagasic cardiomyopathy, in order to search for genetic differences associated with this pathological condition. The frequency of antigen B40 in the presence of antigen Cw3 was found to be significantly lower in subjects with cardiomyopathy. We tentatively suggest that the presence of these antigens noncardiomyopathics is associated with a decreased susceptibility to develop chagasic cardiomyopathy in the Chilean population.

UR - https://www.scopus.com/pages/publications/0023787192

M3 - Article

C2 - 3189340

AN - SCOPUS:0023787192

SN - 0002-9297

VL - 43

SP - 770

EP - 773

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 5

ER -

HLA Antigens in cardiomyopathic Chilean chagasics

Abstract

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