Esquizofrenia resistente: Definiciones e Implicancias del concepto de Esquizofrenia Resistente a tratamiento

Pizarro Galleguillos Benjamín; Óscar Waissbluth; Álvaro Cavieres; Pablo R. Moya; M. Leonor Bustamante

doi:10.4067/S0717-92272019000400394

Esquizofrenia resistente: Definiciones e Implicancias del concepto de Esquizofrenia Resistente a tratamiento

Translated title of the contribution: Treatment resistant schizophrenia: Definitions and implications of the Treatment Resistant Schizophrenia concept

Pizarro Galleguillos Benjamín
, Óscar Waissbluth
, Álvaro Cavieres
, Pablo R. Moya
, M. Leonor Bustamante

Universidad de Chile
Clínica Los Tiempos
Universidad de Valparaíso

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Schizophrenia (SZ) is a highly heterogeneous clinical entity. It causes a severe disruption in quality of life, and it imposes a significant burden to society. Antipsychotics are the first line treatment, however up to a 30% of the patients will present resistance to treatment. Treatment resistant schizophrenia (TRS) could be a neurobiologically distinct disorder and not merely an extremely severe form of SZ. However, there is no consensus in the literature as to the definition of TRS. In the present work we review different definitions of TRS, mainly from clinical guidelines. Furthermore, we discuss therapeutic alternatives for TRS and suggest future perspectives regarding the identification of response predictors and understanding the neurobiology of TRS.

Translated title of the contribution	Treatment resistant schizophrenia: Definitions and implications of the Treatment Resistant Schizophrenia concept
Original language	Spanish
Pages (from-to)	394-404
Number of pages	11
Journal	Revista Chilena de Neuro-Psiquiatria
Volume	57
Issue number	4
DOIs	https://doi.org/10.4067/S0717-92272019000400394
State	Published - 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.4067/S0717-92272019000400394

Cite this

@article{4339817abb3449b59e745c9ead9d22b7,

title = "Esquizofrenia resistente: Definiciones e Implicancias del concepto de Esquizofrenia Resistente a tratamiento",

abstract = "Schizophrenia (SZ) is a highly heterogeneous clinical entity. It causes a severe disruption in quality of life, and it imposes a significant burden to society. Antipsychotics are the first line treatment, however up to a 30\% of the patients will present resistance to treatment. Treatment resistant schizophrenia (TRS) could be a neurobiologically distinct disorder and not merely an extremely severe form of SZ. However, there is no consensus in the literature as to the definition of TRS. In the present work we review different definitions of TRS, mainly from clinical guidelines. Furthermore, we discuss therapeutic alternatives for TRS and suggest future perspectives regarding the identification of response predictors and understanding the neurobiology of TRS.",

keywords = "Antipsychotics, Clozapine, Treatment resistant",

author = "Benjam{\'i}n, \{Pizarro Galleguillos\} and {\'O}scar Waissbluth and {\'A}lvaro Cavieres and Moya, \{Pablo R.\} and \{Leonor Bustamante\}, M.",

year = "2019",

doi = "10.4067/S0717-92272019000400394",

language = "Spanish",

volume = "57",

pages = "394--404",

journal = "Revista Chilena de Neuro-Psiquiatria",

issn = "0034-7388",

number = "4",

}

TY - JOUR

T1 - Esquizofrenia resistente

T2 - Definiciones e Implicancias del concepto de Esquizofrenia Resistente a tratamiento

AU - Benjamín, Pizarro Galleguillos

AU - Waissbluth, Óscar

AU - Cavieres, Álvaro

AU - Moya, Pablo R.

AU - Leonor Bustamante, M.

PY - 2019

Y1 - 2019

N2 - Schizophrenia (SZ) is a highly heterogeneous clinical entity. It causes a severe disruption in quality of life, and it imposes a significant burden to society. Antipsychotics are the first line treatment, however up to a 30% of the patients will present resistance to treatment. Treatment resistant schizophrenia (TRS) could be a neurobiologically distinct disorder and not merely an extremely severe form of SZ. However, there is no consensus in the literature as to the definition of TRS. In the present work we review different definitions of TRS, mainly from clinical guidelines. Furthermore, we discuss therapeutic alternatives for TRS and suggest future perspectives regarding the identification of response predictors and understanding the neurobiology of TRS.

AB - Schizophrenia (SZ) is a highly heterogeneous clinical entity. It causes a severe disruption in quality of life, and it imposes a significant burden to society. Antipsychotics are the first line treatment, however up to a 30% of the patients will present resistance to treatment. Treatment resistant schizophrenia (TRS) could be a neurobiologically distinct disorder and not merely an extremely severe form of SZ. However, there is no consensus in the literature as to the definition of TRS. In the present work we review different definitions of TRS, mainly from clinical guidelines. Furthermore, we discuss therapeutic alternatives for TRS and suggest future perspectives regarding the identification of response predictors and understanding the neurobiology of TRS.

KW - Antipsychotics

KW - Clozapine

KW - Treatment resistant

UR - https://www.scopus.com/pages/publications/85079742710

U2 - 10.4067/S0717-92272019000400394

DO - 10.4067/S0717-92272019000400394

M3 - Article

AN - SCOPUS:85079742710

SN - 0034-7388

VL - 57

SP - 394

EP - 404

JO - Revista Chilena de Neuro-Psiquiatria

JF - Revista Chilena de Neuro-Psiquiatria

IS - 4

ER -

Esquizofrenia resistente: Definiciones e Implicancias del concepto de Esquizofrenia Resistente a tratamiento

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this