Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Claudia Arias-Calvachi; Rancés Blanco; Gloria M. Calaf; Francisco Aguayo

doi:10.3390/biology11060799

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Translated title of the contribution: Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Claudia Arias-Calvachi
, Rancés Blanco
, Gloria M. Calaf
, Francisco Aguayo

Universidad de Chile
Columbia University

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

Translated title of the contribution	Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives
Original language	English
Article number	799
Journal	Biology
Volume	11
Issue number	6
DOIs	https://doi.org/10.3390/biology11060799
State	Published - 23 May 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Carcinogenesis
Epstein–Barr virus

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10.3390/biology11060799License: CC BY

Cite this

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title = "Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives",

abstract = "Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.",

keywords = "Breast cancer, Carcinogenesis, Epstein–Barr virus, C{\'a}ncer de mama, Carcinog{\'e}nesis, Virus de Epstein-Barr",

author = "Claudia Arias-Calvachi and Ranc{\'e}s Blanco and Calaf, \{Gloria M.\} and Francisco Aguayo",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = may,

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doi = "10.3390/biology11060799",

language = "English",

volume = "11",

journal = "Biology",

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TY - JOUR

T1 - Epstein–Barr Virus Association with Breast Cancer

T2 - Evidence and Perspectives

AU - Arias-Calvachi, Claudia

AU - Blanco, Rancés

AU - Calaf, Gloria M.

AU - Aguayo, Francisco

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

AB - Epstein–Barr virus (EBV) is an enveloped DNA virus that belongs to the gamma Her-pesviridae family. The virus establishes a latent/lytic persistent infection, though it can be involved in cancer development in some subjects. Indeed, evidence supports an etiological role of EBV in undifferentiated nasopharyngeal carcinoma (NPC), a subset of gastric carcinomas and lymphomas. Additionally, EBV has been detected in breast carcinomas (BCs) although its role has not been estab-lished. In this review, we summarize epidemiological information regarding the presence of EBV in BC and we propose mechanistic models. However, additional epidemiological and experimental evidence is warranted to confirm these models.

KW - Breast cancer

KW - Carcinogenesis

KW - Epstein–Barr virus

KW - Cáncer de mama

KW - Carcinogénesis

KW - Virus de Epstein-Barr

UR - https://www.scopus.com/pages/publications/85131383699

U2 - 10.3390/biology11060799

DO - 10.3390/biology11060799

M3 - Review article

AN - SCOPUS:85131383699

SN - 2079-7737

VL - 11

JO - Biology

JF - Biology

IS - 6

M1 - 799

ER -

Epstein–Barr Virus Association with Breast Cancer: Evidence and Perspectives

Abstract

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Keywords

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