Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration

M. Divya Gnaneswari; C. Raghavan; L. Bruno Chandrasekar; M. Karunakaran; L. Saravanan; S. Vimal; Saravanan Rajendran; Sonaimuthu Mohandoss; Subramanian Palanisamy; J. Thirumalai; P. Shunmuga Sundaram

doi:10.3103/S1068335625602535

Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration

M. Divya Gnaneswari
, C. Raghavan
, L. Bruno Chandrasekar
, M. Karunakaran
, L. Saravanan
, S. Vimal
, Saravanan Rajendran
, Sonaimuthu Mohandoss
, Subramanian Palanisamy
, J. Thirumalai
, P. Shunmuga Sundaram

Department of Mechanical Engineering

University of Delhi
Gandhigram Rural University
Karpagam Academy of Higher Education
Alagappa Government Arts College
Saveetha Institute of Medical and Technical Sciences (Deemed to be University)
Yeungnam University
Gangneung-Wonju National University
SASTRA

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.

Original language	English
Pages (from-to)	395-408
Number of pages	14
Journal	Bulletin of the Lebedev Physics Institute
Volume	52
Issue number	8
DOIs	https://doi.org/10.3103/S1068335625602535
State	Published - Aug 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MTT assay
Vanadium
apoptosis
colon cancer
septicemia

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10.3103/S1068335625602535

Cite this

Gnaneswari, M. D., Raghavan, C., Chandrasekar, L. B., Karunakaran, M., Saravanan, L., Vimal, S., Rajendran, S., Mohandoss, S., Palanisamy, S., Thirumalai, J., & Sundaram, P. S. (2025). Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration. Bulletin of the Lebedev Physics Institute, 52(8), 395-408. https://doi.org/10.3103/S1068335625602535

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title = "Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration",

abstract = "Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.",

keywords = "MTT assay, Vanadium, apoptosis, colon cancer, septicemia",

author = "Gnaneswari, \{M. Divya\} and C. Raghavan and Chandrasekar, \{L. Bruno\} and M. Karunakaran and L. Saravanan and S. Vimal and Saravanan Rajendran and Sonaimuthu Mohandoss and Subramanian Palanisamy and J. Thirumalai and Sundaram, \{P. Shunmuga\}",

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year = "2025",

month = aug,

doi = "10.3103/S1068335625602535",

language = "English",

volume = "52",

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Gnaneswari, MD, Raghavan, C, Chandrasekar, LB, Karunakaran, M, Saravanan, L, Vimal, S, Rajendran, S, Mohandoss, S, Palanisamy, S, Thirumalai, J & Sundaram, PS 2025, 'Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration', Bulletin of the Lebedev Physics Institute, vol. 52, no. 8, pp. 395-408. https://doi.org/10.3103/S1068335625602535

TY - JOUR

T1 - Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles

T2 - Effect of Doping Concentration

AU - Gnaneswari, M. Divya

AU - Raghavan, C.

AU - Chandrasekar, L. Bruno

AU - Karunakaran, M.

AU - Saravanan, L.

AU - Vimal, S.

AU - Rajendran, Saravanan

AU - Mohandoss, Sonaimuthu

AU - Palanisamy, Subramanian

AU - Thirumalai, J.

AU - Sundaram, P. Shunmuga

PY - 2025/8

Y1 - 2025/8

N2 - Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.

AB - Abstract: Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.

KW - MTT assay

KW - Vanadium

KW - apoptosis

KW - colon cancer

KW - septicemia

UR - https://www.scopus.com/pages/publications/105016718636

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DO - 10.3103/S1068335625602535

M3 - Article

AN - SCOPUS:105016718636

SN - 1068-3356

VL - 52

SP - 395

EP - 408

JO - Bulletin of the Lebedev Physics Institute

JF - Bulletin of the Lebedev Physics Institute

IS - 8

ER -

Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration

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Keywords

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