Distribution of ADH2 and ALDH2 genotypes in different populations

H. W. Goedde; D. P. Agarwal; G. Fritze; D. Meier-Tackmann; S. Singh; G. Beckmann; K. Bhatia; L. Z. Chen; B. Fang; R. Lisker; Y. K. Paik; F. Rothhammer; N. Saha; B. Segal; L. M. Srivastava; A. Czeizel

doi:10.1007/BF00197271

Distribution of ADH₂ and ALDH2 genotypes in different populations

H. W. Goedde
, D. P. Agarwal
, G. Fritze
, D. Meier-Tackmann
, S. Singh
, G. Beckmann
, K. Bhatia
, L. Z. Chen
, B. Fang
, R. Lisker
, Y. K. Paik
, F. Rothhammer
, N. Saha
, B. Segal
, L. M. Srivastava
, A. Czeizel

University of Hamburg
Umeå University
Papua New Guinea Institute of Medical Research
Women's and Children's Hospital Adelaide
Institute of Basic Medical Sciences
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hanyang University
Universidad de Chile
National University Hospital
University of Alaska Anchorage
All India Institute of Medical Sciences, New Delhi
National Institute of Hygiene Budapest

Research output: Contribution to journal › Article › peer-review

516 Scopus citations

Abstract

The distribution of the human liver alcohol dehydrogenase, ADH₂, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH₁ ²allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH₂ ²gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH2²) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

Original language	English
Pages (from-to)	344-346
Number of pages	3
Journal	Human Genetics
Volume	88
Issue number	3
DOIs	https://doi.org/10.1007/BF00197271
State	Published - Jan 1992
Externally published	Yes

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10.1007/BF00197271

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@article{2d5545ac6b3641d2a1b2c1cb57c33129,

title = "Distribution of ADH2 and ALDH2 genotypes in different populations",

abstract = "The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.",

author = "Goedde, \{H. W.\} and Agarwal, \{D. P.\} and G. Fritze and D. Meier-Tackmann and S. Singh and G. Beckmann and K. Bhatia and Chen, \{L. Z.\} and B. Fang and R. Lisker and Paik, \{Y. K.\} and F. Rothhammer and N. Saha and B. Segal and Srivastava, \{L. M.\} and A. Czeizel",

year = "1992",

month = jan,

doi = "10.1007/BF00197271",

language = "English",

volume = "88",

pages = "344--346",

journal = "Human Genetics",

issn = "0340-6717",

number = "3",

}

TY - JOUR

T1 - Distribution of ADH2 and ALDH2 genotypes in different populations

AU - Goedde, H. W.

AU - Agarwal, D. P.

AU - Fritze, G.

AU - Meier-Tackmann, D.

AU - Singh, S.

AU - Beckmann, G.

AU - Bhatia, K.

AU - Chen, L. Z.

AU - Fang, B.

AU - Lisker, R.

AU - Paik, Y. K.

AU - Rothhammer, F.

AU - Saha, N.

AU - Segal, B.

AU - Srivastava, L. M.

AU - Czeizel, A.

PY - 1992/1

Y1 - 1992/1

N2 - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

AB - The distribution of the human liver alcohol dehydrogenase, ADH2, and aldehyde dehydrogenase, ALDH2, genotypes in 21 different populations comprising Mongoloids, Caucasoids, and Negroids was determined by hybridization of the amplified genomic DNA with allele-specific oligonucleotide probes. Whereas the frequency of the ADH1 2allele was found to be relatively high in the Caucasoids, Mexican Mestizos, Brazilian Indios, Swedish Lapps, Papua New Guineans and Negroids, the frequency of the ADH2 2gene was considerably higher in the Mongoloids and Australian Aborigines. The atypical ALDH2 gene (ALDH22) was found to be extremely rare in Caucasoids, Negroids, Papua New Guineans, Australian Aborigines and Aurocanians (South Chile). In contrast, this mutant gene was found to be widely prevalent among the Mongoloids. Individuals possessing the abnormal ALDH2 gene show alcohol-related sensitivity responses (e.g. facial flushing), have the tendency not to be habitual drinkers, and apparently suffer less from alcoholism and alcohol-related liver disease.

UR - https://www.scopus.com/pages/publications/0026609541

U2 - 10.1007/BF00197271

DO - 10.1007/BF00197271

M3 - Article

C2 - 1733836

AN - SCOPUS:0026609541

SN - 0340-6717

VL - 88

SP - 344

EP - 346

JO - Human Genetics

JF - Human Genetics

IS - 3

ER -

Distribution of ADH₂ and ALDH2 genotypes in different populations

Abstract

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