TY - JOUR
T1 - Contrasting Patterns of Nuclear and mtDNA Diversity in Native American Populations
AU - Yang, Ning Ning
AU - Mazières, Stephane
AU - Bravi, Claudio
AU - Ray, Nicolas
AU - Wang, Sijia
AU - Burley, Mari Wyn
AU - Bedoya, Gabriel
AU - Rojas, Winston
AU - Parra, Maria V.
AU - Molina, Julio A.
AU - Gallo, Carla
AU - Poletti, Giovanni
AU - Hill, Kim
AU - Hurtado, Ana M.
AU - Petzl-Erler, Maria L.
AU - Tsuneto, Luiza T.
AU - Klitz, William
AU - Barrantes, Ramiro
AU - Llop, Elena
AU - Rothhammer, Francisco
AU - Labuda, Damian
AU - Salzano, Francisco M.
AU - Bortolini, Maria Cátira
AU - Excoffier, Laurent
AU - Dugoujon, Jean Michel
AU - Ruiz-Linares, Andrés
PY - 2010/11
Y1 - 2010/11
N2 - We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.
AB - We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.
KW - Ameriindians
KW - MtDNA
KW - STRs
KW - X-chromosome
KW - Y-chromosome
UR - https://www.scopus.com/pages/publications/77958189047
U2 - 10.1111/j.1469-1809.2010.00608.x
DO - 10.1111/j.1469-1809.2010.00608.x
M3 - Article
AN - SCOPUS:77958189047
SN - 0003-4800
VL - 74
SP - 525
EP - 538
JO - Annals of Human Genetics
JF - Annals of Human Genetics
IS - 6
ER -