Abstract
Intermittent hypobaric hypoxia (IHH) induced a decrease in sperm count and oxidative damage in epididymis. We have previously demonstrated that a blueberry-enriched polyphenol extract (BB-4) reduced the adverse effects of oxidative stress in rat testis under hypobaric hypoxia. The aim of this study was to evaluate whether BB-4 could reverse oxidative stress in epididymis. To evaluate the protective role of BB-4 in epididymis, male rats were exposed to IHH. Lipid peroxidation, (LPO) expression and activity of glutathione reductase (GR) were evaluated. Our results showed a reduction in LPO and a decrease in GR activity in rat epididymis exposed to IHH. These results suggest that BB-4 can prevent the effects of IHH in rat epididymis.
| Original language | English |
|---|---|
| Pages (from-to) | 766-769 |
| Number of pages | 4 |
| Journal | Andrologia |
| Volume | 46 |
| Issue number | 7 |
| DOIs | |
| State | Published - Sep 2014 |
Keywords
- Epididymis
- Hypobaric hypoxia
- Infertility
- Oxidative stress
- Polyphenols
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